| pubmed-article:2984031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0014259 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0443224 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2984031 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2984031 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2984031 | pubmed:dateCreated | 1985-5-8 | lld:pubmed |
| pubmed-article:2984031 | pubmed:abstractText | Homogenates of fresh bovine corneal endothelium and of cells from primary cultures exhibited high affinity binding of [3H]-dihydroalprenolol, a specific beta-adrenergic antagonist. The binding was rapid and reversible. Specific binding of the radioligand in each preparation was saturable with half-maximal binding occurring at 0.5 nM. Homogenates of fresh tissue consistently showed a higher maximal binding capacity than did those from cell cultures. Both homogenates bound adrenergic agents in a manner consistent with the labelling of beta-adrenergic receptors. The relative affinities of epinephrine and norepinephrine indicated that beta-adrenergic receptors in both preparations are of the beta 2 subtype. The beta-adrenergic agonist, isoproterenol, increased the cAMP content of intact, cultured endothelial cells 27-fold over control. This effect was completely blocked by the beta-adrenergic antagonist, propranolol. Bovine corneal endothelial cells in primary culture contain beta-adrenergic receptors which are essentially identical to those from in vivo sources and appear to be linked functionally to cAMP synthesis in these cells. | lld:pubmed |
| pubmed-article:2984031 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2984031 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2984031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2984031 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2984031 | pubmed:issn | 0014-4835 | lld:pubmed |
| pubmed-article:2984031 | pubmed:author | pubmed-author:BylundD BDB | lld:pubmed |
| pubmed-article:2984031 | pubmed:author | pubmed-author:WalkenbachR... | lld:pubmed |
| pubmed-article:2984031 | pubmed:author | pubmed-author:ChanW SWS | lld:pubmed |
| pubmed-article:2984031 | pubmed:author | pubmed-author:GibbsS RSR | lld:pubmed |
| pubmed-article:2984031 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2984031 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:2984031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2984031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2984031 | pubmed:pagination | 15-21 | lld:pubmed |
| pubmed-article:2984031 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:meshHeading | pubmed-meshheading:2984031-... | lld:pubmed |
| pubmed-article:2984031 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2984031 | pubmed:articleTitle | Characterization of beta-adrenergic receptors in fresh and primary cultured bovine corneal endothelium. | lld:pubmed |
| pubmed-article:2984031 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2984031 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2984031 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
