| pubmed-article:2983307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0330232 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C1419053 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2983307 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2983307 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2983307 | pubmed:dateCreated | 1985-3-27 | lld:pubmed |
| pubmed-article:2983307 | pubmed:abstractText | Platelet-activating factor (PAF) is a potent lipid mediator of inflammation and asthma. Using a receptor preparation of rabbit platelet membranes, we identified a novel antagonist of PAF in the methylene chloride extract of a Chinese herbal plant, haifenteng (Piper futokadsura). The active antagonist, kadsurenone, was isolated and characterized in several in vitro and in vivo assays. It is a specific and competitive inhibitor of PAF binding to its receptor with a Ki of 5.8 X 10(-8) M vs. a Ki of 6.3 X 10(-9) M for PAF itself. It inhibits PAF-induced aggregation of rabbit platelets and human neutrophils at 2.4-24 microM, without showing any PAF agonistic activity. It potently inhibits PAF-induced degranulation of human neutrophils at 2.5-50 microM, also without any agonist activity. Kadsurenone is active orally at 25-50 mg/kg of body weight in blocking PAF-induced cutaneous permeability in the guinea pig. It also inhibits PAF-induced increases of hematocrit and circulating N-acetylglucosaminidase in the rat at greater than 10 mg/kg i.p. in a dose-dependent manner. Kadsurenone does not interfere with the function of several pharmacological mediators and receptors tested. Its structural specificity is evidenced by the poor PAF-antagonistic activities of three related structures isolated from the same haifenteng extract. | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2983307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2983307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2983307 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2983307 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:HwangS BSB | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:LalM MMM | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:ShenT YTY | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:SuM OMO | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:DoebberT WTW | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:ChangM NMN | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:LiR ZRZ | lld:pubmed |
| pubmed-article:2983307 | pubmed:author | pubmed-author:YaoX RXR | lld:pubmed |
| pubmed-article:2983307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2983307 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2983307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2983307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2983307 | pubmed:pagination | 672-6 | lld:pubmed |
| pubmed-article:2983307 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:meshHeading | pubmed-meshheading:2983307-... | lld:pubmed |
| pubmed-article:2983307 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2983307 | pubmed:articleTitle | Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. | lld:pubmed |
| pubmed-article:2983307 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2983307 | lld:pubmed |
