| pubmed-article:2973611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0003015 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0151814 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0109227 | lld:lifeskim |
| pubmed-article:2973611 | lifeskim:mentions | umls-concept:C0055220 | lld:lifeskim |
| pubmed-article:2973611 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2973611 | pubmed:dateCreated | 1988-12-30 | lld:pubmed |
| pubmed-article:2973611 | pubmed:abstractText | The present study was designed to examine the effects of two new angiotensin-converting enzyme (ACE) inhibitors, CGS 14831 and CGS 16617 (3 mg/kg i. v. 1 min prior to occlusion and 4 and 24 h after occlusion), on myocardial ischemic (MI) damage and left-ventricular hypertrophy in rats. Administration of CGS 14831 or CGS 16617 inhibited angio-tensin-I-induced pressor responses by 40-100% for 4 h after each dose. Myocardial creatine phosphokinase (CK) levels were 10.6 +/- 0.6 U/mg protein in sham-MI animals, and following coronary artery occlusion for 48 h were decreased to 4.1 +/- 0.2 U/mg protein in MI + vehicle animals (p less than 0.01). CGS 14831 and CGS 16617 attenuated the decrease in CK content and resulted in 47 and 40% sparing, respectively, of the left-ventricular free wall. Neither agent attenuated the left-ventricular hypertrophy which developed following coronary artery occlusion. These data indicate that the nonsulfhydryl ACE inhibitors CGS 14831 and CGS 16617 have a significant cardioprotective effect in rats surviving 48 h, and suggest a potential therapeutic usefulness of these agents for the treatment of ischemia-induced heart failure. | lld:pubmed |
| pubmed-article:2973611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2973611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2973611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2973611 | pubmed:issn | 0031-7012 | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:GoodmanF RFR | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:SmithE FEF3rd | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:RibeiroL GLG | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:ZimmermanM... | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:VEISII | lld:pubmed |
| pubmed-article:2973611 | pubmed:author | pubmed-author:EganJ WJW | lld:pubmed |
| pubmed-article:2973611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2973611 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:2973611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2973611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2973611 | pubmed:pagination | 254-63 | lld:pubmed |
| pubmed-article:2973611 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:meshHeading | pubmed-meshheading:2973611-... | lld:pubmed |
| pubmed-article:2973611 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2973611 | pubmed:articleTitle | Effects of two nonsulfhydryl angiotensin-converting enzyme inhibitors, CGS 14831 and CGS 16617, on myocardial damage and left-ventricular hypertrophy following coronary artery occlusion in the rat. | lld:pubmed |
| pubmed-article:2973611 | pubmed:affiliation | Research Department, Ciba-Geigy Corp., Summit, N.J. | lld:pubmed |
| pubmed-article:2973611 | pubmed:publicationType | Journal Article | lld:pubmed |
