| pubmed-article:2973566 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:2973566 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
| pubmed-article:2973566 | pubmed:issue | 6198 | lld:pubmed |
| pubmed-article:2973566 | pubmed:dateCreated | 1989-1-3 | lld:pubmed |
| pubmed-article:2973566 | pubmed:abstractText | Cytolytic T lymphocytes (CTLs) are generally thought to recognize cellular antigens presented by class I MHC molecules. A number of studies, however, have revealed responses of considerable magnitude involving both CD8+ and CD4+ CTLs with class II restriction, suggesting that class II-restricted CTLs recognizing exogeneous protein antigens may exist. As class II antigens are normally expressed on limited types of cells such as B cells and macrophages, such CTLs might be expected to exert a suppressive effect on antibody responses. Here we report that stimulation of mouse lymphocytes with a soluble antigen induced CD8+ and CD4+ CTLs specific for the antigen with class II restriction. The specific lysis was far more efficient when target B cells specifically recognized the antigen than when they did not, indicating that the primary targets for these CTLs are probably B cells expressing immunoglobulin receptors reactive for the same antigen molecule. These results suggest that the natural occurrence of such CTLs during immune responses may explain antigen-specific suppression on antibody responses by T cells. | lld:pubmed |
| pubmed-article:2973566 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2973566 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2973566 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2973566 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2973566 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2973566 | pubmed:author | pubmed-author:WatanabeMM | lld:pubmed |
| pubmed-article:2973566 | pubmed:author | pubmed-author:SachsD HDH | lld:pubmed |
| pubmed-article:2973566 | pubmed:author | pubmed-author:ShinoharaNN | lld:pubmed |
| pubmed-article:2973566 | pubmed:author | pubmed-author:HozumiNN | lld:pubmed |
| pubmed-article:2973566 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2973566 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2973566 | pubmed:volume | 336 | lld:pubmed |
| pubmed-article:2973566 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2973566 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2973566 | pubmed:pagination | 481-4 | lld:pubmed |
| pubmed-article:2973566 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:2973566 | pubmed:meshHeading | pubmed-meshheading:2973566-... | lld:pubmed |
| pubmed-article:2973566 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2973566 | pubmed:articleTitle | Killing of antigen-reactive B cells by class II-restricted, soluble antigen-specific CD8+ cytolytic T lymphocytes. | lld:pubmed |
| pubmed-article:2973566 | pubmed:affiliation | Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:2973566 | pubmed:publicationType | Journal Article | lld:pubmed |
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