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pubmed-article:2966886pubmed:abstractTextThe aziridinium ion of ethylcholine (AF64A) is a neurotoxin that has demonstrated selectivity for cholinergic neurons. Unilateral stereotaxic injection of AF64A into the caudate-putamen of rats, resulted in a decrease in dopamine D-2 receptors as evidenced by a decrease in [3H]-sulpiride binding. Dopamine D-1 receptors, labeled with [3H]-SCH 23390, were unchanged. The efficacy of the lesion was demonstrated by the reduction of Na+-dependent high affinity choline uptake sites labeled with [3H]-hemicholinium-3. These data indicate that a population of D-2 receptors are postsynaptic on cholinergic interneurons within the striatum of rat brain.lld:pubmed
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pubmed-article:2966886pubmed:articleTitleEvidence for dopamine D-2 receptors on cholinergic interneurons in the rat caudate-putamen.lld:pubmed
pubmed-article:2966886pubmed:affiliationDepartment of Psychiatry, University of Utah Medical Center, Salt Lake City 84132.lld:pubmed
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