Linked Life Data

2966802

Source:http://linkedlifedata.com/resource/pubmed/id/2966802

Statements in which the resource exists.
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pubmed-article:2966802pubmed:abstractTextPlasminogen activation by tissue-type plasminogen activator (t-PA) is stimulated by fibrin. In a purified system maximal fibrin-enhanced plasmin formation occurs with a delay after an initial phase of slow plasmin formation (lag phase). In the present study purified stimulating CNBr-fragment FCB-2 of fibrinogen was used, and kinetics of plasminogen activation by t-PA were analyzed with respect to the lag phase. At constant FCB-2 concentration the duration of the lag phase decreased with increasing concentrations of t-PA and plasminogen. During this period the rate of plasmin formation/min increased linearly with time with a slope dependent on the initial concentrations of FCB-2, plasminogen, and t-PA. Plasmin pretreatment of FCB-2 resulted in a dose- and time-dependent shortening of the lag phase, and at plasmin concentrations greater than or equal to 1 nM and preincubation times greater than or equal to 3 min maximal plasmin formation occurred without a lag phase. Kinetics during the phase of maximal and constant plasmin formation were not influenced by plasmin pretreatment of FCB-2. We therefore conclude that maximal t-PA-dependent plasmin formation in a system stimulated by purified FCB-2 requires plasmin modification of FCB-2.lld:pubmed
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pubmed-article:2966802pubmed:authorpubmed-author:GeigerMMlld:pubmed
pubmed-article:2966802pubmed:authorpubmed-author:BeckmannRRlld:pubmed
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pubmed-article:2966802pubmed:pagination7176-80lld:pubmed
pubmed-article:2966802pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:2966802pubmed:year1988lld:pubmed
pubmed-article:2966802pubmed:articleTitlePlasminogen activation by tissue plasminogen activator in the presence of stimulating CNBr fragment FCB-2 of fibrinogen is a two-phase reaction. Kinetic analysis of the initial phase of slow plasmin formation.lld:pubmed
pubmed-article:2966802pubmed:affiliationDepartment of Medical Physiology, University of Vienna, Austria.lld:pubmed
pubmed-article:2966802pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2966802pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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