| pubmed-article:2958544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0123263 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2958544 | lifeskim:mentions | umls-concept:C0439098 | lld:lifeskim |
| pubmed-article:2958544 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2958544 | pubmed:dateCreated | 1987-11-4 | lld:pubmed |
| pubmed-article:2958544 | pubmed:abstractText | Culture of murine splenic B cells with interleukin 4 (IL-4) caused the up-regulation of the lymphocyte Fc receptor for immunoglobulin E (IgE) (Fc epsilon R) over a similar dose range as required for Ia up-regulation. However, the expression level of the Fc receptor for immunoglobulin G (Fc gamma R) did not increase, rather IL-4 caused a slight but consistent decrease in the Fc gamma R level on the B cells. Fc epsilon R+ B hybridoma cells also responded to IL-4 by exhibiting increased Fc epsilon R expression; with the hybridoma cells Fc gamma R levels were unaffected. IL-4 caused an increase in the number of Fc epsilon R per cell and the highest levels of expression were obtained by having both IgE and IL-4 present in the culture. The specificity of the increase was demonstrated by blocking IL-4-mediated actions with monoclonal anti-IL-4 (11B11). Experiments following the incorporation of [35S]methionine into the Fc epsilon R demonstrated that IL-4 increased the rate of Fc epsilon R biosynthesis; this provides an explanation for the IL-4-induced increase in Fc epsilon R expression. IL-4, unlike IgE, had no effect on the rate of degradation of the Fc epsilon R. Interferon-gamma (IFN-gamma) totally abrogated IL-4-mediated Fc epsilon R up-regulation; at the same concentration of IFN-gamma Ia up-regulation is also suppressed, although not as effectively. IFN-gamma was shown to directly suppress Fc epsilon R synthesis, thereby explaining the inhibitory action on Fc epsilon R levels. Finally, it was shown that 11B11 inhibited the increased expression of Fc epsilon R on B cells obtained from mice during the early, but not the late, stages of Nippostrongylus brasiliensis infection. This latter finding suggests that the high Fc epsilon R levels seen early in parasite infections are dependent upon IL-4. The results overall provide further insight into the biologic activities of IL-4. | lld:pubmed |
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| pubmed-article:2958544 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2958544 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2958544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2958544 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2958544 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:RayGG | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:LynchR GRG | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:ConradD HDH | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:LeeW TWT | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:NoelleR JRJ | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:KeeganA DAD | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:WaldschmidtT... | lld:pubmed |
| pubmed-article:2958544 | pubmed:author | pubmed-author:KehryM RMR | lld:pubmed |
| pubmed-article:2958544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2958544 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2958544 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:2958544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2958544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2958544 | pubmed:pagination | 2290-6 | lld:pubmed |
| pubmed-article:2958544 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2958544 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2958544 | pubmed:articleTitle | Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines. | lld:pubmed |
| pubmed-article:2958544 | pubmed:affiliation | Subdepartment of Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21205. | lld:pubmed |
| pubmed-article:2958544 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2958544 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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