| pubmed-article:2948496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0027096 | lld:lifeskim |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2948496 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:2948496 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2948496 | pubmed:dateCreated | 1987-1-28 | lld:pubmed |
| pubmed-article:2948496 | pubmed:abstractText | The patterns of myosin isoenzymes in fast- and slow-twitch muscles of the rat hindlimb were studied, by pyrophosphate/polyacrylamide-gel electrophoresis, with hypertrophy (induced by synergist removal) and with spontaneous running exercise of 4 and 11 weeks duration. At 11 weeks, changes with hypertrophy in the slow-twitch soleus, composed of greater than 95% SM2 (slow myosin 2) in normal muscles, were minor, and consisted of an increase in the SM1 and SM1', and a loss of intermediate myosin (IM), an isoenzyme characteristic of Type IIa fibres [Fitzsimons & Hoh (1983) J. Physiol. (London) 343, 539-550]. The changes were dramatic, however, in the fast-twitch plantaris muscle. There was a 3-fold increase in the proportion of SM. In addition, IM became the predominant isoenzyme in the profile of hypertrophied plantaris by 4 weeks. These increases were balanced by decreases in the proportion of FM2 (fast myosin 2), with FM1 completely absent from the profile at 11 weeks. The changes in the plantaris with exercise were similar in direction but not as extensive as those with hypertrophy, and FM1 remained present at control levels throughout the study. When hypertrophy and exercise were combined, the increase in slow myosin was equal to the sum of the increases with each treatment alone. Changes at 4 weeks were intermediate between those of control and 11-week muscles. Peptide mapping of individual myosin isoenzymes showed that the heavy chains of IM were different from either fast or slow heavy chains. Furthermore, IM was found to be composed of a mixture of fast and slow light chains. These changes suggest that a transformation of myosin from fast to slow isoforms was in progress in the plantaris in response to hypertrophy, via a Type-IIa-myosin (IM) intermediate stage, a phenomenon similar to that occurring in chronically stimulated fast muscles during fast-to-slow transformation [Brown, Salmons & Whalen (1983) J. Biol. Chem. 258, 14686-14692]. | lld:pubmed |
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| pubmed-article:2948496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2948496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2948496 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2948496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2948496 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2948496 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2948496 | pubmed:author | pubmed-author:GregoryPP | lld:pubmed |
| pubmed-article:2948496 | pubmed:author | pubmed-author:LowR BRB | lld:pubmed |
| pubmed-article:2948496 | pubmed:author | pubmed-author:StirewaltW... | lld:pubmed |
| pubmed-article:2948496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2948496 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2948496 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:2948496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2948496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2948496 | pubmed:pagination | 55-63 | lld:pubmed |
| pubmed-article:2948496 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:2948496 | pubmed:meshHeading | pubmed-meshheading:2948496-... | lld:pubmed |
| pubmed-article:2948496 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2948496 | pubmed:articleTitle | Changes in skeletal-muscle myosin isoenzymes with hypertrophy and exercise. | lld:pubmed |
| pubmed-article:2948496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2948496 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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