| pubmed-article:2945890 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0123242 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2945890 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:2945890 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2945890 | pubmed:dateCreated | 1986-12-3 | lld:pubmed |
| pubmed-article:2945890 | pubmed:abstractText | The expression of Fc epsilon R on human lymphocytes was studied with the anti-Fc epsilon R mAbs. Fc epsilon R was expressed on most mu+,delta+ circulating B cells, whereas T cells did not express Fc epsilon R even in patients with hyper-IgE syndrome. B cells with gamma, alpha, or epsilon phenotype did not express Fc epsilon R, moreover its expression could not be induced, suggesting that the Fc epsilon R expression was correlated with isotype switching. mu+delta+ B cells in bone marrow did not express Fc epsilon R, but PHA-sup (supernatant from PHA-stimulated cell cultures) could induce its expression, and the addition of IgE augmented this induction. Recombinant IL-2, IL-1, IFN-gamma or -beta, or purified B cell differentiation factor (BSF-2 B cell-stimulatory factor 2) could not induce Fc epsilon R expression in bone marrow B cells. IFN-gamma inhibited the Fc epsilon R expression induced by PHA-sup, suggesting that the human counterpart of BSF-1 may be responsible for Fc epsilon R expression in bone marrow B cells. B cells from patients with common variable immunodeficiency and ataxia telangiectasia did not express Fc epsilon R, but PHA-sup could induce its expression, indicating that circulating B cells of these patients are at a differentiation stage similar to B cells in bone marrow. The study showed that Fc epsilon R is a B cell-specific differentiation marker, the expression of which is restricted to a defined stage of B cell differentiation. | lld:pubmed |
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| pubmed-article:2945890 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2945890 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2945890 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2945890 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2945890 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:NakamuraHH | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:SatoRR | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:YamasakiKK | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:KishimotoTT | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:SuemuraMM | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:KikutaniHH | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:BarsumianE... | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:HardyR RRR | lld:pubmed |
| pubmed-article:2945890 | pubmed:author | pubmed-author:OwakiHH | lld:pubmed |
| pubmed-article:2945890 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2945890 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2945890 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:2945890 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2945890 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2945890 | pubmed:pagination | 1455-69 | lld:pubmed |
| pubmed-article:2945890 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2945890 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2945890 | pubmed:articleTitle | Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. | lld:pubmed |
| pubmed-article:2945890 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2945890 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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