| pubmed-article:2942562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:2942562 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:2942562 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2942562 | pubmed:dateCreated | 1986-9-17 | lld:pubmed |
| pubmed-article:2942562 | pubmed:abstractText | Utilizing affinity chromatography, a C3-specific binding protein was isolated from 125I surface-labeled human platelets. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated two bands with mean Mr of 64,000 and 53,000, characteristic variability in the relative density of the two bands in a given individual, and the presence of N-linked complex oligosaccharides as well as sialic acid residues not associated with N-linked sugars. These characteristics are similar to those of a human leukocyte iC3- and C3b-binding glycoprotein, termed gp45-70. Further analysis showed that leukocyte gp45-70 and the platelet C3-binding glycoprotein have identical Mr and other similar structural features. Functional characterization of solubilized platelet preparations indicated that gp45-70 has cofactor activity. This membrane glycoprotein is structurally and antigenically distinct from decay accelerating factor (DAF), a complement regulatory protein previously identified on human platelet membranes. DAF and gp45-70 have complementary activity profiles inasmuch as DAF can prevent assembly of and dissociate the C3 convertases but has no cofactor activity, whereas gp45-70 has cofactor activity but no decay accelerating activity. We suggest that these two proteins function conjointly to prevent autologous complement activation. | lld:pubmed |
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| pubmed-article:2942562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2942562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2942562 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2942562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2942562 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2942562 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2942562 | pubmed:author | pubmed-author:AtkinsonJ PJP | lld:pubmed |
| pubmed-article:2942562 | pubmed:author | pubmed-author:YuG HGH | lld:pubmed |
| pubmed-article:2942562 | pubmed:author | pubmed-author:SeyaTT | lld:pubmed |
| pubmed-article:2942562 | pubmed:author | pubmed-author:BallardLL | lld:pubmed |
| pubmed-article:2942562 | pubmed:author | pubmed-author:HolersV MVM | lld:pubmed |
| pubmed-article:2942562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2942562 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:2942562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2942562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2942562 | pubmed:pagination | 494-501 | lld:pubmed |
| pubmed-article:2942562 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2942562 | pubmed:meshHeading | pubmed-meshheading:2942562-... | lld:pubmed |
| pubmed-article:2942562 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2942562 | pubmed:articleTitle | Identification of a third component of complement-binding glycoprotein of human platelets. | lld:pubmed |
| pubmed-article:2942562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2942562 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2942562 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2942562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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