| pubmed-article:2941516 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0678889 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:2941516 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2941516 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2941516 | pubmed:dateCreated | 1986-8-20 | lld:pubmed |
| pubmed-article:2941516 | pubmed:abstractText | The ability of murine Peyer's patch (PP) T contrasuppressor cells (Tcs) to reverse oral tolerance to the T cell-dependent (TD) antigen SRBC was studied both in vivo and in vitro. C3H/HeJ mice given SRBC orally for 4 wk are not rendered tolerant to this antigen and were used as a source of PP Tcs cells for adoptive transfer to identically treated, orally tolerized C3H/HeN mice. Transfer of 10(4) or 5 X 10(4) V. villosa-adherent PP T cells resulted in splenic IgM, IgG, and mainly IgA responses in C3H/HeN mice challenged systemically with SRBC. The T cell responsible was Lyt-1+, 2-, L3T4-, I-JK+ and V. villosa lectin-adherent, all characteristics of mature effector Tcs cells. This C3H/HeJ PP Tcs cell subset was also effective when added to in vitro cultures of tolerized spleen cells derived from SRBC-fed, C3H/HeN mice. Interestingly, C3H/HeJ PP Tcs cells restored mainly IgA responses when transferred in vivo or when added to suppressed C3H/HeN splenic cultures. Comparison of the functional activity of Tcs cells derived from spleen or PP of orally immunized C3H/HeJ mice revealed that splenic Tcs cells supported responses of all 3 isotypes; however, PP Tcs cells yielded three-fourfold higher IgA responses, when compared with IgM or IgG anti-SRBC responses. Adherence of C3H/HeJ PP Tcs to an Fc alpha R+ T cell line derived from IgA-specific Th cells resulted in a nonadherent cell fraction that potentiated only IgM and IgG responses, while bound Tcs cells preferentially supported IgA responses. These results suggest that murine PP contain IgA-specific Tcs cells that allow IgA response induction in the presence of Ts cells that mediate oral tolerance. | lld:pubmed |
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| pubmed-article:2941516 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2941516 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2941516 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2941516 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2941516 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2941516 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:SuzukiII | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:KuritaTT | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:KitamuraKK | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:GreenD RDR | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:McGheeJ RJR | lld:pubmed |
| pubmed-article:2941516 | pubmed:author | pubmed-author:KiyonoHH | lld:pubmed |
| pubmed-article:2941516 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2941516 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2941516 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:2941516 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2941516 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2941516 | pubmed:pagination | 501-16 | lld:pubmed |
| pubmed-article:2941516 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2941516 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2941516 | pubmed:articleTitle | Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. | lld:pubmed |
| pubmed-article:2941516 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2941516 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2941516 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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