| pubmed-article:2935600 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2935600 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2935600 | lifeskim:mentions | umls-concept:C0011185 | lld:lifeskim |
| pubmed-article:2935600 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2935600 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:2935600 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2935600 | pubmed:dateCreated | 1986-3-21 | lld:pubmed |
| pubmed-article:2935600 | pubmed:abstractText | Liver metabolites and in vitro enzyme activities were measured in Sprague-Dawley rats pair-fed the standard NIH diet with or without 0.6% (wt/wt) dehydroepiandrosterone (DHEA) for 16 d. Absorption of DHEA from the gut was confirmed by a 300-fold increase in urine 17-ketosteroids in DHEA-treated animals. Of the liver metabolites measured only 6-phosphogluconate was significantly changed, increasing by less than a factor of two in the DHEA-treated animals, 38.7 +/- 2.2 nmol/g, above the value in the pair-fed controls, 22.5 +/- 2.5 nmol/g. Contrary to the in vitro findings that DHEA inhibits glucose-6-phosphate dehydrogenase (EC 1.1.1.49), thus leading to the hypothesis that DHEA inhibits fat synthesis by diminishing the availability of NADPH, the [NADP+]/[NADPH] ratios calculated from the 6-phosphogluconate dehydrogenase (EC 1.1.1.44), isocitrate dehydrogenase (EC 1.1.1.42) and malic enzyme (EC 1.1.1.40) redox couples were no more oxidized in the DHEA-treated animals than in the control animals. Malic enzyme and isocitrate dehydrogenase activities were 620 and 25% higher in DHEA-treated animals than in pair-fed controls. There was no change in the measured activity of glucose-6-phosphate dehydrogenase or 6-phosphogluconate dehydrogenase. These data give no support to the hypothesis that administration of DHEA per os results in decreased cytoplasmic NADPH in liver. | lld:pubmed |
| pubmed-article:2935600 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2935600 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2935600 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2935600 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2935600 | pubmed:issn | 0022-3166 | lld:pubmed |
| pubmed-article:2935600 | pubmed:author | pubmed-author:VeechR LRL | lld:pubmed |
| pubmed-article:2935600 | pubmed:author | pubmed-author:CasazzaJ PJP | lld:pubmed |
| pubmed-article:2935600 | pubmed:author | pubmed-author:SchafferW TWT | lld:pubmed |
| pubmed-article:2935600 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2935600 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:2935600 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2935600 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2935600 | pubmed:pagination | 304-10 | lld:pubmed |
| pubmed-article:2935600 | pubmed:dateRevised | 2011-10-3 | lld:pubmed |
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| pubmed-article:2935600 | pubmed:meshHeading | pubmed-meshheading:2935600-... | lld:pubmed |
| pubmed-article:2935600 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2935600 | pubmed:articleTitle | The effect of dehydroepiandrosterone on liver metabolites. | lld:pubmed |
| pubmed-article:2935600 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2935600 | lld:pubmed |
