| pubmed-article:2933138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0002475 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0016343 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0031928 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C1561451 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C1522326 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C1292734 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2933138 | lifeskim:mentions | umls-concept:C0220283 | lld:lifeskim |
| pubmed-article:2933138 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2933138 | pubmed:dateCreated | 1986-1-16 | lld:pubmed |
| pubmed-article:2933138 | pubmed:abstractText | Concurrent administration of degradable starch microspheres and cytostatic agents into the hepatic artery results in decreased systemic exposure and increased hepatic exposure to drug compared to intra-arterial administration of drug alone. Degradable starch microspheres 210 mg/m2 mixed with floxuridine 500 mg/m2, doxorubicin 40 gm/m2, and mitomycin 10 mg/m2 were administered through hepatic artery catheters to eleven patients with primary or metastatic cancer of the liver. Toxicity was acceptable and consisted of severe myelosuppression (5%), duodenal/gastric ulceration (9%), mild to moderate nausea and vomiting (17%) and alopecia (86%). There were no responses among the eleven patients; 7 of 7 patients with colo-rectal carcinoma had stable disease while on study. Minimal activity was observed in 7 patients with colo-rectal carcinoma. The use of degradable starch microspheres offers a new approach to the regional treatment of cancer and warrants further study. | lld:pubmed |
| pubmed-article:2933138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2933138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2933138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2933138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2933138 | pubmed:issn | 0732-9482 | lld:pubmed |
| pubmed-article:2933138 | pubmed:author | pubmed-author:BooksteinJ... | lld:pubmed |
| pubmed-article:2933138 | pubmed:author | pubmed-author:HowellS BSB | lld:pubmed |
| pubmed-article:2933138 | pubmed:author | pubmed-author:PfeifleC ECE | lld:pubmed |
| pubmed-article:2933138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2933138 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2933138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2933138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2933138 | pubmed:pagination | 305-11 | lld:pubmed |
| pubmed-article:2933138 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:meshHeading | pubmed-meshheading:2933138-... | lld:pubmed |
| pubmed-article:2933138 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2933138 | pubmed:articleTitle | Pilot study of intra-arterial floxuridine, mitomycin and doxorubicin in combination with degradable starch microspheres to treat primary and metastatic tumors of the liver. | lld:pubmed |
| pubmed-article:2933138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2933138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2933138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2933138 | lld:pubmed |
