| pubmed-article:2930511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:2930511 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2930511 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2930511 | pubmed:dateCreated | 1989-5-4 | lld:pubmed |
| pubmed-article:2930511 | pubmed:abstractText | This study investigated whether the same cytochrome P-450 (P-450) isoenzymes were inducible in cultures of chick-embryo hepatocytes as in the liver of chicken embryos. We purified two isoenzymes of cytochrome P-450 from the livers of 17-day-old-chick embryos: one of molecular mass approx. 50 kDa induced in vivo by the phenobarbital-like inducer glutethimide, and the second of approx. 57 kDa induced by 3-methylcholanthrene. Rabbit antiserum against the 50 kDa protein inhibited benzphetamine demethylase activity in hepatic microsomes (microsomal fractions) from glutethimide-treated chick embryo. Antiserum to the 57 kDa protein inhibited ethoxyresorufin de-ethylase activity in hepatic microsomes from methylcholanthrene-treated chick embryo. Cultured chick hepatocytes were treated with chemicals known to induce isoenzymes of P-450 in rodent liver. The induced P-450s were quantified spectrophotometrically and characterized by immunoblotting and enzyme assays. From these studies, chemical inducers were classified into three groups: (i) chemicals that induced a P-450 isoenzyme of 50 kDa and increased benzphetamine demethylase activity: glutethimide, phenobarbital, metyrapone, mephenytoin, ethanol, isopentanol, isobutanol, lindane, lysodren; (ii) chemicals that induced a P-450 isoenzyme of 57 kDa and increased ethoxyresorufin de-ethylase activity: 3-methylcholanthrene and 3,3',4,4'-tetrachlorobiphenyl; and (iii) the mono-alpha-substituted 2,3',4,4',5-pentabromobiphenyl, which induced both proteins and both activities. The immunochemical data showed that chick-embryo hepatocytes in culture retain the inducibility of glutethimide- and methylcholanthrene-induced isoenzymes of P-450 that are inducible in the liver of the chicken embryo. | lld:pubmed |
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| pubmed-article:2930511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2930511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2930511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2930511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2930511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2930511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2930511 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2930511 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:SinclairJJ | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:SinclairPP | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:HealeyJJ | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:HaugenSS | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:BonkovskyHH | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:FrezzaJJ | lld:pubmed |
| pubmed-article:2930511 | pubmed:author | pubmed-author:BementWW | lld:pubmed |
| pubmed-article:2930511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2930511 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2930511 | pubmed:volume | 258 | lld:pubmed |
| pubmed-article:2930511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2930511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2930511 | pubmed:pagination | 237-45 | lld:pubmed |
| pubmed-article:2930511 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2930511 | pubmed:meshHeading | pubmed-meshheading:2930511-... | lld:pubmed |
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| pubmed-article:2930511 | pubmed:meshHeading | pubmed-meshheading:2930511-... | lld:pubmed |
| pubmed-article:2930511 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2930511 | pubmed:articleTitle | Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures. | lld:pubmed |
| pubmed-article:2930511 | pubmed:affiliation | Veterans Administration Hospital, White River Junction, VT 05001. | lld:pubmed |
| pubmed-article:2930511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2930511 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2930511 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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