| pubmed-article:2924129 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:2924129 | lifeskim:mentions | umls-concept:C0034795 | lld:lifeskim |
| pubmed-article:2924129 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2924129 | pubmed:dateCreated | 1989-4-28 | lld:pubmed |
| pubmed-article:2924129 | pubmed:abstractText | Several recent investigations have reported a decline of rat hippocampal corticosteroid-binding receptors (CSRs) with aging. This decline has been proposed to be an initial cause (through disinhibition) of the elevated adrenal steroid secretion that apparently occurs with aging; however, it could instead be an effect of corticoid elevation (through down-regulation). In order to assess the effects of age on CSR biosynthetic capacity in the absence of down-regulatory influences of endogenous corticoids, as well as to study aging changes in CSR plasticity, we examined the up-regulation of hippocampal CSR that follows adrenalectomy (ADX). The rat hippocampus contains at least two types of CSR binding and differential analysis of types I and II CSR was accomplished by selective displacement of [3H]corticosterone with RU-28362, a specific type II agonist. In young (3 months old) Fischer-344 rat hippocampus, up-regulation of type II binding above 2-day ADX baseline was present by 3-7 days and increased still further by 8-10 days post-ADX; type I CSR density did not change significantly between 1 and 10 days post-ADX. However, in aged (24-26 months old) rats, type II CSR up-regulation did not occur over the 10 day post-ADX period. Thus, the age-related impairment of type II up-regulation may reflect an intrinsic deficit in CSR biosynthesis or lability that is independent of the acute endogenous adrenal steroid environment. | lld:pubmed |
| pubmed-article:2924129 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2924129 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2924129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2924129 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2924129 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2924129 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2924129 | pubmed:author | pubmed-author:EldridgeJ CJC | lld:pubmed |
| pubmed-article:2924129 | pubmed:author | pubmed-author:LandfieldP... | lld:pubmed |
| pubmed-article:2924129 | pubmed:author | pubmed-author:KerrD SDS | lld:pubmed |
| pubmed-article:2924129 | pubmed:author | pubmed-author:FleenorD GDG | lld:pubmed |
| pubmed-article:2924129 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2924129 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:2924129 | pubmed:volume | 478 | lld:pubmed |
| pubmed-article:2924129 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2924129 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2924129 | pubmed:pagination | 248-56 | lld:pubmed |
| pubmed-article:2924129 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:meshHeading | pubmed-meshheading:2924129-... | lld:pubmed |
| pubmed-article:2924129 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2924129 | pubmed:articleTitle | Impaired up-regulation of type II corticosteroid receptors in hippocampus of aged rats. | lld:pubmed |
| pubmed-article:2924129 | pubmed:affiliation | Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103. | lld:pubmed |
| pubmed-article:2924129 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2924129 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2924129 | lld:pubmed |
