pubmed-article:2918500 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2918500 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
pubmed-article:2918500 | lifeskim:mentions | umls-concept:C0031957 | lld:lifeskim |
pubmed-article:2918500 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:2918500 | pubmed:dateCreated | 1989-4-6 | lld:pubmed |
pubmed-article:2918500 | pubmed:abstractText | The iodinated analogue of 1-[2-(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP), IPAPP (4), and the corresponding azido compound azido-IPAPP (5) were synthesized. The corresponding no-carrier-added 125I (T1/2 = 60 days, 35-60 keV) labeled compounds were also prepared. High specific binding was observed from in vitro binding studies using rat brain tissue preparation; Ki = 20 and 17.5 nM against [3H]-5-HT. In vivo biodistribution studies in rats showed that azido-[125I]IPAPP passed through intact blood-brain barrier and localized in the brain. Ex vivo autoradiography of rat brain sections exhibited a diffuse uptake pattern, which may be due to specific and nonspecific binding. The results indicate that IPAPP and azido-IPAPP may not be suitable to image the serotonin receptor in the brain. | lld:pubmed |
pubmed-article:2918500 | pubmed:language | eng | lld:pubmed |
pubmed-article:2918500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2918500 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2918500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2918500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2918500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2918500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2918500 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2918500 | pubmed:month | Mar | lld:pubmed |
pubmed-article:2918500 | pubmed:issn | 0022-2623 | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:MARSP HPH | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:WuYY | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:RATHF WFW | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:GuoY ZYZ | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:ChumpraditSS | lld:pubmed |
pubmed-article:2918500 | pubmed:author | pubmed-author:BillingsJJ | lld:pubmed |
pubmed-article:2918500 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2918500 | pubmed:volume | 32 | lld:pubmed |
pubmed-article:2918500 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2918500 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2918500 | pubmed:pagination | 543-7 | lld:pubmed |
pubmed-article:2918500 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:2918500 | pubmed:year | 1989 | lld:pubmed |
pubmed-article:2918500 | pubmed:articleTitle | Preparation and biodistribution of 1-[2-(3-[125I]iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl) phenyl]piperazine and 1-[2-(3-[125I]iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl] piperazine. | lld:pubmed |
pubmed-article:2918500 | pubmed:affiliation | Department of Radiology, University of Pennsylvania, Philadelphia 19104. | lld:pubmed |
pubmed-article:2918500 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2918500 | pubmed:publicationType | In Vitro | lld:pubmed |
http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:2918500 | lld:chembl |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2918500 | lld:pubmed |