Linked Life Data

2909293

Source:http://linkedlifedata.com/resource/pubmed/id/2909293

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pubmed-article:2909293pubmed:abstractTextTo determine whether oxygen metabolites can cause ductus relaxation, we used rings of fetal ductus obtained from 36 near-term lambs and measured the effects of the oxygen metabolites generated by the combination of hypoxanthine and xanthine oxidase. The oxygen metabolites produced by hypoxanthine plus xanthine oxidase caused relaxation of the ductus that was inhibited by catalase (hydrogen peroxide scavenger) but not by superoxide dismutase (superoxide anion scavenger). In addition, hypoxanthine plus xanthine oxidase produced a 14-fold increase in prostaglandin (PG) E2 production with only twofold increase in 6-keto-PGF1 alpha (the stable metabolite of PGI2). PGE2 is the most potent relaxant of the ductus arteriosus. The presence of either catalase or indomethacin blocked both the increase in prostaglandin production and the relaxation. We conclude that reactive oxygen metabolites relax the ductus arteriosus and oppose the normal constriction that occurs after birth. However, the vasoactive effects of reactive oxygen metabolites in the ductus appear to be mediated exclusively through the generation of PGE2.lld:pubmed
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pubmed-article:2909293pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:2909293pubmed:year1989lld:pubmed
pubmed-article:2909293pubmed:articleTitleReactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production.lld:pubmed
pubmed-article:2909293pubmed:affiliationCardiovascular Research Institute, University of California, San Francisco 94143.lld:pubmed
pubmed-article:2909293pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2909293pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:2909293pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2909293pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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