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pubmed-article:2907038pubmed:abstractTextThe antihistamine and anticholinergic properties of mequitazine have been investigated and compared with those of clemizole. Both mequitazine and clemizole antagonized the effect of histamine in guinea-pig ileum competitively, the pA2 values calculated by Schild plot were 9.95 +/- 0.44 for mequitazine and 10.54 +/- 0.44 for clemizole. Mequitazine at 10(-7) M produced a parallel shift of the dose-response curve to acetylcholine in the rat duodenum, clemizole and the lower doses of mequitazine failed to modify the effect of acetylcholine. The potency of mequitazine and clemizole as H1-histamine blockers is similar, but only mequitazine at highest concentration used showed anticholinergic activity.lld:pubmed
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pubmed-article:2907038pubmed:articleTitleAntihistaminic and anticholinergic activities of mequitazine in comparison with clemizole.lld:pubmed
pubmed-article:2907038pubmed:affiliationDepartment de Farmacologia i Farmacotecnia, Universitat de Valencia, Facultat de Medicina, Spain.lld:pubmed
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