| pubmed-article:2903932 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C1260969 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:2903932 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:2903932 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2903932 | pubmed:dateCreated | 1989-1-12 | lld:pubmed |
| pubmed-article:2903932 | pubmed:abstractText | Several analogues of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxa n (WB 4101, 1) were prepared and evaluated for their blocking activity on alpha 1- and alpha 2-adrenoreceptors in the isolated rat vas deferens. The results were compared with those obtained for 1 and benoxathian (2). It was shown that the two oxygens at positions 1 and 4 may have a different role in receptor binding. It seems that the oxygen at position 4 as such does not contribute to the binding while it is important in stabilizing an optimal conformation for drug-receptor interaction mechanism. On the other hand, the oxygen at position 1 might interact with a receptor polar pocket of reduced size by way of a donor-acceptor dipolar interaction. Furthermore, it was shown that replacement of the dehydrodioxane ring of 1 by a phenyl or a pyrrole nucleus causes a significant decrease in activity. | lld:pubmed |
| pubmed-article:2903932 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2903932 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903932 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2903932 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2903932 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:GuliniUU | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:MelchiorreCC | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:GiardinàDD | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:BrasiliLL | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:GiannellaMM | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:PiginiMM | lld:pubmed |
| pubmed-article:2903932 | pubmed:author | pubmed-author:QuagliaWW | lld:pubmed |
| pubmed-article:2903932 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2903932 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2903932 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2903932 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2903932 | pubmed:pagination | 2300-4 | lld:pubmed |
| pubmed-article:2903932 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2903932 | pubmed:meshHeading | pubmed-meshheading:2903932-... | lld:pubmed |
| pubmed-article:2903932 | pubmed:meshHeading | pubmed-meshheading:2903932-... | lld:pubmed |
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| pubmed-article:2903932 | pubmed:meshHeading | pubmed-meshheading:2903932-... | lld:pubmed |
| pubmed-article:2903932 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2903932 | pubmed:articleTitle | Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha 1-adrenoreceptor blocking activity. | lld:pubmed |
| pubmed-article:2903932 | pubmed:affiliation | Department of Chemical Sciences, University of Camerino, Italy. | lld:pubmed |
| pubmed-article:2903932 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2903932 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2903932 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:2903932 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2903932 | lld:pubmed |
