| pubmed-article:2903078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C0282549 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C1149592 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2903078 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:2903078 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2903078 | pubmed:dateCreated | 1988-12-22 | lld:pubmed |
| pubmed-article:2903078 | pubmed:abstractText | When the human myeloid leukemia cell line (HL60) is induced to differentiate with retinoic acid (RA), there is a concentration-dependent increase in transglutaminase (TGase) activity which peaks on day 5. While dibutyryl 3',5'-cyclic adenosine monophosphate (db-cAMP) alone produced only a slight increase in TGase activity in HL60 cells, the concomitant addition of db-cAMP (100 microM) with RA (10(-12)-10(-4) M) potentiates RA induction of TGase activity. Maximal increases in TGase activity (2- to 10-fold) were observed with 10(-4)-10(-7) M RA and when db-cAMP was present from 24 to 48 h after the addition of RA. The cyclic nucleotide enhancement was dose-dependent from 10 to 100 microM of cAMP. Less marked increases were observed with 8-bromo-cAMP and with the phosphodiesterase inhibitor theophylline. Although the simultaneous addition of PGE1 or PGE2 (10(-8)-10(-6) M) produced no enhancement of RA-induced TGase activity, adding PGE1 or PGE2 24 or 48 h following RA treatments produced an enhancement of TGase activity. The phosphodiesterase inhibitor potentiated the increases produced by db-cAMP and the prostaglandins. Dibutyryl cAMP enhanced the ability of RA to induce the cells to reduce nitroblue tetrazolium (NBT), a functional measure of differentiation, at lower concentrations of RA and with shorter treatment durations. cAMP potentiates RA-induced TGase activity in HL60 cells and the combination appears to be associated with enhanced RA-induced differentiation. | lld:pubmed |
| pubmed-article:2903078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2903078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2903078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2903078 | pubmed:issn | 0304-3568 | lld:pubmed |
| pubmed-article:2903078 | pubmed:author | pubmed-author:HaddoxM KMK | lld:pubmed |
| pubmed-article:2903078 | pubmed:author | pubmed-author:MaddoxA MAM | lld:pubmed |
| pubmed-article:2903078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2903078 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:2903078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2903078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2903078 | pubmed:pagination | 49-59 | lld:pubmed |
| pubmed-article:2903078 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2903078 | pubmed:meshHeading | pubmed-meshheading:2903078-... | lld:pubmed |
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| pubmed-article:2903078 | pubmed:meshHeading | pubmed-meshheading:2903078-... | lld:pubmed |
| pubmed-article:2903078 | pubmed:meshHeading | pubmed-meshheading:2903078-... | lld:pubmed |
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| pubmed-article:2903078 | pubmed:meshHeading | pubmed-meshheading:2903078-... | lld:pubmed |
| pubmed-article:2903078 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2903078 | pubmed:articleTitle | Characteristics of cyclic AMP enhancement of retinoic acid induction of increased transglutaminase activity in HL60 cells. | lld:pubmed |
| pubmed-article:2903078 | pubmed:affiliation | Department of Internal Medicine, University of Texas Medical School, Houston. | lld:pubmed |
| pubmed-article:2903078 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2903078 | lld:pubmed |
