| pubmed-article:2901097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2901097 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:2901097 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:2901097 | lifeskim:mentions | umls-concept:C0031667 | lld:lifeskim |
| pubmed-article:2901097 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2901097 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:2901097 | pubmed:dateCreated | 1988-10-6 | lld:pubmed |
| pubmed-article:2901097 | pubmed:abstractText | Human recombinant interleukin 1 alpha (IL-1 alpha) and IL-1 beta stimulated prostaglandin E2 synthesis in 3T3 fibroblasts in a time- and concentration-dependent manner. Enhanced prostaglandin E2 synthesis after IL-1 treatment was apparent by 1 hr and continued to increase for at least 2 days. Half-maximal stimulation occurred at 0.5 pM IL-1 alpha or IL-1 beta, and both interleukins were equally effective, with maximal stimulation occurring in response to 5-10 pM IL-1. In contrast to IL-1, bradykinin stimulation of prostaglandin E2 synthesis is rapid; its effect is maximal by 5 min. In cells that had been pretreated with IL-1 for 24 hr, prostaglandin E2 synthesis in response to bradykinin was amplified more than 10-fold. IL-1 also amplified the receptor-mediated formation of prostaglandin E2 by bombesin and thrombin. The lymphokine did not affect bradykinin receptor number or affinity. IL-1 treatment induced phospholipase A2 and cyclooxygenase but not phospholipase C or prostaglandin E isomerase. It also enhanced bradykinin-stimulated GTPase activity, suggesting possible induction of the GTP-binding regulatory protein coupled to the bradykinin receptor. Thus, IL-1 enhanced receptor-mediated release of prostaglandin E2 in response to bradykinin, bombesin, and thrombin by increasing the cellular levels of phospholipase A2, cyclooxygenase, and GTP-binding regulatory protein(s). | lld:pubmed |
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| pubmed-article:2901097 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2901097 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2901097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2901097 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2901097 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2901097 | pubmed:author | pubmed-author:AxelrodJJ | lld:pubmed |
| pubmed-article:2901097 | pubmed:author | pubmed-author:BurchR MRM | lld:pubmed |
| pubmed-article:2901097 | pubmed:author | pubmed-author:ConnorJ RJR | lld:pubmed |
| pubmed-article:2901097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2901097 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2901097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2901097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2901097 | pubmed:pagination | 6306-9 | lld:pubmed |
| pubmed-article:2901097 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2901097 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2901097 | pubmed:articleTitle | Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts. | lld:pubmed |
| pubmed-article:2901097 | pubmed:affiliation | National Institute of Mental Health, Laboratory of Cell Biology, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:2901097 | pubmed:publicationType | Journal Article | lld:pubmed |
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