| pubmed-article:2900919 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0032143 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0155626 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C0520997 | lld:lifeskim |
| pubmed-article:2900919 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2900919 | pubmed:issue | 8610 | lld:pubmed |
| pubmed-article:2900919 | pubmed:dateCreated | 1988-10-5 | lld:pubmed |
| pubmed-article:2900919 | pubmed:abstractText | 13,318 patients admitted to fifty-two coronary care units with suspected acute myocardial infarction were considered for inclusion in a double-blind study comparing recombinant tissue-type plasminogen activator (rt-PA) 100 mg plus heparin with placebo plus heparin. 8307 (62%) were excluded, mainly because their symptoms had begun more than 5 h previously, but all excluded patients were followed up at least until hospital discharge. 2516 patients were randomly allocated to rt-PA and 2495 to placebo. At one month the overall case fatality rates were 7.2% and 9.8%, respectively, a relative reduction of 26% (95% confidence interval 11-39%). 6.3% of patients given rt-PA had a bleeding complication (1.4% major) compared with 0.8% given placebo (0.4% major). However, the incidence of stroke was similar--1.1% in the rt-PA group and 1.0% in the placebo group. Subset analysis showed that patients who had a normal electrocardiogram (ECG) at the time of randomisation (17.5% of the whole trial population) had a low case fatality rate (1.6% in those given rt-PA compared with 3.0% in those given placebo). In those with an abnormal ECG at entry, rt-PA was associated with a 24.5% relative reduction in 1 month fatality (95% confidence interval 9-37%). | lld:pubmed |
| pubmed-article:2900919 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2900919 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2900919 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2900919 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2900919 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2900919 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:HamptonJ RJR | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:WilcoxR GRG | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:OlssonC GCG | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:JensenGG | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:von der... | lld:pubmed |
| pubmed-article:2900919 | pubmed:author | pubmed-author:SkeneA MAM | lld:pubmed |
| pubmed-article:2900919 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2900919 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:2900919 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2900919 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2900919 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2900919 | pubmed:pagination | 525-30 | lld:pubmed |
| pubmed-article:2900919 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2900919 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2900919 | pubmed:articleTitle | Trial of tissue plasminogen activator for mortality reduction in acute myocardial infarction. Anglo-Scandinavian Study of Early Thrombolysis (ASSET). | lld:pubmed |
| pubmed-article:2900919 | pubmed:affiliation | Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham. | lld:pubmed |
| pubmed-article:2900919 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2900919 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2900919 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:2900919 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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