| pubmed-article:2899322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0034843 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2899322 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:2899322 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:2899322 | pubmed:dateCreated | 1988-8-24 | lld:pubmed |
| pubmed-article:2899322 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2899322 | pubmed:abstractText | We have isolated a c-erbA cDNA clone from a GH3 cell library. The clone, denoted erb62, is 4.5 kilobases long and encodes a 461-amino acid beta-type c-erbA protein. This c-erbA protein binds 3,5,3'-triiodothyronine (T3) and T3 analogs with affinities similar to those of the authentic T3 receptor. By RNA gel blot analysis, erb62 hybridizes to a 6-kilobase RNA found in organs that express T3 receptors--e.g., heart, kidney, and brain. A COS-cell transient cotransfection system was used to show that erb62 encodes a biologically active T3 receptor. An oligonucleotide, corresponding to a portion of the rat growth hormone gene 5'-flanking region that contains a T3 response element, was inserted on the 5' side of the herpes simplex virus thymidine kinase promoter in a chloramphenicol acetyltransferase-expressing plasmid. Reporter gene expression directed by this hybrid promoter was T3 inducible only if this plasmid was cotransfected with an erb62-expressing plasmid. | lld:pubmed |
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| pubmed-article:2899322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2899322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2899322 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2899322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2899322 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2899322 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:LarsenP RPR | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:KoenigR JRJ | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:MooreD DDD | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:HarneyJ WJW | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:BrentG AGA | lld:pubmed |
| pubmed-article:2899322 | pubmed:author | pubmed-author:WarneR LRL | lld:pubmed |
| pubmed-article:2899322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2899322 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2899322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2899322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2899322 | pubmed:pagination | 5031-5 | lld:pubmed |
| pubmed-article:2899322 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2899322 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2899322 | pubmed:articleTitle | Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. | lld:pubmed |
| pubmed-article:2899322 | pubmed:affiliation | Howard Hughes Medical Institute Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2899322 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2899322 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2899322 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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