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pubmed-article:2897853pubmed:abstractTextWe reported previously that, in the perfused rat liver, oleic acid increased the specific activity of cytosolic enzymes of cholesterol biosynthesis. In this study, we examined the effects of oral administration of olive oil on the activities of HMG-CoA synthase, AcAc-CoA thiolase, AcAc-CoA ligase and HMG-CoA reductase. Olive oil feeding increased the specific activity of hepatic HMG-CoA synthase by 50%, AcAc-CoA thiolase by 2-fold, and AcAc-CoA ligase by 3-fold. Olive oil had no effect on HMG-CoA reductase activity. These data suggest that the enzymes that supply the HMG-CoA required for hepatic cholesterogenesis are regulated in parallel by a physiological substrate, fatty acid, independent of HMG-CoA reductase under these conditions.lld:pubmed
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pubmed-article:2897853pubmed:articleTitleRegulation of hepatic cholesterol biosynthesis by fatty acids: effect of feeding olive oil on cytoplasmic acetoacetyl-coenzyme A thiolase, beta-hydroxy-beta-methylglutaryl-CoA synthase, and acetoacetyl-coenzyme A ligase.lld:pubmed
pubmed-article:2897853pubmed:affiliationDepartment of Pharmacology, College of Medicine, University of Tennessee, Memphis 38163.lld:pubmed
pubmed-article:2897853pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2897853pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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