| pubmed-article:2896234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0023448 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0028606 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0062169 | lld:lifeskim |
| pubmed-article:2896234 | lifeskim:mentions | umls-concept:C0053733 | lld:lifeskim |
| pubmed-article:2896234 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2896234 | pubmed:dateCreated | 1988-6-8 | lld:pubmed |
| pubmed-article:2896234 | pubmed:abstractText | Although the parent sesquiterpene lactone, helenalin, and its derivative, bis(helenalinyl)malonate, are structurally related chemically, they demonstrate differences in their antineoplastic activity, with bis(helenalinyl)malonate being much more active against P-388 lymphocytic leukemia cell growth (T/C% = 261) compared with helenalin (T/C% = 162). Previous studies have shown that both agents strongly inhibit protein synthesis in vivo by greater than 70% after 3 d of administration and in vitro by 50% at a 100 microM concentration of drug. This inhibition of protein synthesis of P-388 cells may be partially responsible for the cytotoxicity of the drug. These agents also inhibit nucleic acid synthesis in vivo, with DNA synthesis being suppressed by greater than 90% after 2 d of administration of drugs at the therapeutic dose. Of the sulfhydryl-bearing enzymes involved in nucleic acid synthesis that were assayed, only the activities of inosine-5'-monophosphate (IMP) dehydrogenase and the ribonucleotide reductase complex were inhibited by greater than 50% by these sulfhydryl-reactive drugs, which would account for the observed inhibition of nucleic acid synthesis in the P-388 cells. The inhibition of the activities of these enzymes lowered the deoxyribonucleotide levels in P-388 cells, which would explain the overall suppression of DNA synthesis by the sesquiterpene lactones. | lld:pubmed |
| pubmed-article:2896234 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2896234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2896234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2896234 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2896234 | pubmed:issn | 0022-3549 | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:HallI HIH | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:LeeK HKH | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:ChaneyS GSG | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:WilliamsW... | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:GrippoA AAA | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:HolbrookD JDJ | lld:pubmed |
| pubmed-article:2896234 | pubmed:author | pubmed-author:OswaldC BCB | lld:pubmed |
| pubmed-article:2896234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2896234 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:2896234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2896234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2896234 | pubmed:pagination | 178-84 | lld:pubmed |
| pubmed-article:2896234 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:meshHeading | pubmed-meshheading:2896234-... | lld:pubmed |
| pubmed-article:2896234 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2896234 | pubmed:articleTitle | Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo. | lld:pubmed |
| pubmed-article:2896234 | pubmed:affiliation | Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27514. | lld:pubmed |
| pubmed-article:2896234 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2896234 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2896234 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
