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pubmed-article:2893593pubmed:abstractTextThe effect of somatostatin (SS-14) was tested in an anesthetized rabbit model of closed-loop ileal obstruction. Experimental groups included (1) immediate treatment (N = 6) receiving SS-14 2,000 pmol X kg-1 X h-1 intravenously (I.V.) beginning at the time of ileal obstruction, (2) delayed treatment (N = 5) receiving SS-14 beginning 6 hours following ileal obstruction, and (3) control (N = 6) receiving only hydration. After 24 hours, all rabbits were killed. Significantly decreased intestinal luminal volume and sodium and potassium output was observed with both immediate and delayed SS-14 treatment when compared to control. Additionally, the gross and microscopic pathologic features of intestinal distension, inflammation, and necrosis seen in control rabbits were absent in rabbits treated with SS-14. The known broad spectrum of physiologic activity of SS-14 on the gastrointestinal tract appeared beneficial in this rabbit model of intestinal obstruction.lld:pubmed
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pubmed-article:2893593pubmed:articleTitleThe effect of somatostatin on experimental intestinal obstruction.lld:pubmed
pubmed-article:2893593pubmed:affiliationDepartment of Surgery, University of California, San Francisco 94143-0104.lld:pubmed
pubmed-article:2893593pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2893593pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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