| pubmed-article:2884014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C0005210 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C0013786 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C1269776 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C1879743 | lld:lifeskim |
| pubmed-article:2884014 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:2884014 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2884014 | pubmed:dateCreated | 1987-7-14 | lld:pubmed |
| pubmed-article:2884014 | pubmed:abstractText | Electrical stimulation of the ventral midbrain periaqueductal grey (PAG) elicited an antinociception (analgesia) in freely moving rats. Stimulated animals displayed a pronounced decrease in levels of immunoreactive (ir)-beta-endorphin (beta-EP) in the midbrain PAG. This depletion was selective in that: animals placed in the chamber and not stimulated revealed neither an analgesia nor an alteration in levels of ir-beta-EP. No change in levels of ir-beta-EP was detectable in other brain regions. Both stimulated rats and rats placed in the chamber and not stimulated revealed a rise in circulating ir-beta-EP: the magnitude of this rise did not, however, differ between these groups. Levels of ir-Met-enkephalin, ir-Leu-enkephalin and ir-dynorphin A were modified neither in the PAG nor in other CNS tissues. The data demonstrate that electrical stimulation of the midbrain PAG selectively influences (presumably activates) pools of beta-EP therein. Together with our finding that destruction of PAG-localized beta-EP neurones to block stimulation-analgesia, the data suggest that an activation of intrinsic pools of beta-EP underlies stimulation-produced analgesia elicited from the PAG in the rat. | lld:pubmed |
| pubmed-article:2884014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2884014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2884014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2884014 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2884014 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2884014 | pubmed:author | pubmed-author:HerzAA | lld:pubmed |
| pubmed-article:2884014 | pubmed:author | pubmed-author:Cz?onkowskiAA | lld:pubmed |
| pubmed-article:2884014 | pubmed:author | pubmed-author:MillarM DMD | lld:pubmed |
| pubmed-article:2884014 | pubmed:author | pubmed-author:MillanM JMJ | lld:pubmed |
| pubmed-article:2884014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2884014 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:2884014 | pubmed:volume | 407 | lld:pubmed |
| pubmed-article:2884014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2884014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2884014 | pubmed:pagination | 199-203 | lld:pubmed |
| pubmed-article:2884014 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:meshHeading | pubmed-meshheading:2884014-... | lld:pubmed |
| pubmed-article:2884014 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2884014 | pubmed:articleTitle | Activation of periaqueductal grey pools of beta-endorphin by analgetic electrical stimulation in freely moving rats. | lld:pubmed |
| pubmed-article:2884014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2884014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
