| pubmed-article:2880963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2880963 | lifeskim:mentions | umls-concept:C0003385 | lld:lifeskim |
| pubmed-article:2880963 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2880963 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:2880963 | lifeskim:mentions | umls-concept:C0033200 | lld:lifeskim |
| pubmed-article:2880963 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2880963 | pubmed:dateCreated | 1987-4-1 | lld:pubmed |
| pubmed-article:2880963 | pubmed:abstractText | The possibility that proadifen (SKF 525A) antagonizes endothelium-dependent relaxations to acetylcholine (ACh) in isolated blood vessel preparations via a muscarinic receptor blocking action has been investigated. In phenylephrine-contracted rat isolated aortic ring preparations (with endothelium), proadifen (10-100 microM) shifts ACh relaxant curves to the right without affecting the maximal response, yet endothelium-dependent relaxations to ATP are unaffected. At lower concentrations, proadifen (1-10 microM) antagonizes negative inotropic responses to ACh and ATP in guinea-pig left atria, antagonizes contractile responses to ACh and elevated [K+] in guinea-pig ileal preparations, displaces (-)-[3H]quinuclidinyl benzilate from muscarinic binding sites in membrane homogenates of guinea-pig ileal longitudinal muscle and reduces contractile responses to elevated [K+] in rat aortic ring preparations. It is concluded that proadifen may possess complex interactions with muscarinic receptors and Ca2+ entry blocking properties in concentrations 10-100 times lower than those reported to inhibit cytochrome P450-catalysed reactions. | lld:pubmed |
| pubmed-article:2880963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2880963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2880963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2880963 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2880963 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:2880963 | pubmed:author | pubmed-author:MitchelsonFF | lld:pubmed |
| pubmed-article:2880963 | pubmed:author | pubmed-author:MaltaEE | lld:pubmed |
| pubmed-article:2880963 | pubmed:author | pubmed-author:ChooL KLK | lld:pubmed |
| pubmed-article:2880963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2880963 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:2880963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2880963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2880963 | pubmed:pagination | 898-901 | lld:pubmed |
| pubmed-article:2880963 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:meshHeading | pubmed-meshheading:2880963-... | lld:pubmed |
| pubmed-article:2880963 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2880963 | pubmed:articleTitle | Investigation of the antimuscarinic and other actions of proadifen in-vitro. | lld:pubmed |
| pubmed-article:2880963 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2880963 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2880963 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
