| pubmed-article:2878432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C0024779 | lld:lifeskim |
| pubmed-article:2878432 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:2878432 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:2878432 | pubmed:dateCreated | 1987-1-14 | lld:pubmed |
| pubmed-article:2878432 | pubmed:abstractText | The homeotic genes of Drosophila, which regulate pattern formation during larval development, contain a 180-base-pair DNA sequence termed the "homeo-box." Nucleotide sequence comparisons indicate that the homeo-box motif is highly conserved in a variety of motazoan species. As in Drosophila, homeo-box sequences of mammalian species are expressed in a temporal and tissue-specific pattern during embryogenesis. These observations suggest functional homologies between dipteran and mammalian homeo-box gene products. To identify possible relationships between homeo-box genes of mice and humans, we have compared the chromosomal location of homeo-box genes in these species. Using in situ hybridization and somatic cell genetic techniques, we have mapped the chromosome 6-specific murine Hox-1 homolog to the region p14-p21 on human chromosome 7. We have also regionally mapped the murine Hox-3 locus to 15F1-3 and its human cognate to 12q11-q21. These comparative mapping data indicate that a syntenic relationship in mice and humans is maintained for all homeo-box loci examined to date. We suggest these regions represent evolutionarily conserved genomic domains encoding homologous protein products that function in regulating patterns of mammalian development. | lld:pubmed |
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| pubmed-article:2878432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2878432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878432 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2878432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2878432 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2878432 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2878432 | pubmed:author | pubmed-author:RuddleF HFH | lld:pubmed |
| pubmed-article:2878432 | pubmed:author | pubmed-author:RabinMM | lld:pubmed |
| pubmed-article:2878432 | pubmed:author | pubmed-author:HartC PCP | lld:pubmed |
| pubmed-article:2878432 | pubmed:author | pubmed-author:Ferguson-Smit... | lld:pubmed |
| pubmed-article:2878432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2878432 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:2878432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2878432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2878432 | pubmed:pagination | 9104-8 | lld:pubmed |
| pubmed-article:2878432 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:2878432 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2878432 | pubmed:articleTitle | Cognate homeo-box loci mapped on homologous human and mouse chromosomes. | lld:pubmed |
| pubmed-article:2878432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2878432 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2878432 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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