| pubmed-article:2864344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2864344 | lifeskim:mentions | umls-concept:C0030281 | lld:lifeskim |
| pubmed-article:2864344 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:2864344 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:2864344 | lifeskim:mentions | umls-concept:C0301715 | lld:lifeskim |
| pubmed-article:2864344 | lifeskim:mentions | umls-concept:C0597599 | lld:lifeskim |
| pubmed-article:2864344 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:2864344 | pubmed:dateCreated | 1985-11-14 | lld:pubmed |
| pubmed-article:2864344 | pubmed:abstractText | High aminotransferase activities catalyzing the reactions between L-glutamate and L-glutamine and the aliphatic ketomonocarboxylic acids 2-ketoisocaproate, 2-ketocaproate, and 2-ketoisovalerate were observed in pancreatic B-cell mitochondria. While maximal rates of transamination with L-glutamate were observed in the presence of micromolar concentrations of keto acid, maximal rates of transamination with L-glutamine were recorded only in the presence of millimolar concentrations of keto acid. The insulin secretagogue 2-ketoisocaproate was the most effective transamination partner for L-glutamate, while the insulin secretagogue 2-ketocaproate was the most effective transamination partner for L-glutamine. Since B-cell mitochondria are well supplied with L-glutamate and L-glutamine, 2-ketoglutarate generation in the presence of these two neutral 2-keto acids may be an important prerequisite for their insulin secretory potency. High rates of transamination of 2-ketoglutarate were observed in the pancreatic B-cell mitochondria with the branched-chain amino acids L-leucine and L-valine, but not with L-norleucine. In connection with the ability of L-leucine to activate glutamate dehydrogenase, this high activity of the branched-chain amino acid aminotransferase in pancreatic B-cell mitochondria may provide an explanation for the insulin secretory potency of this amino acid. | lld:pubmed |
| pubmed-article:2864344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2864344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2864344 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2864344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2864344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2864344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2864344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2864344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2864344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2864344 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2864344 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2864344 | pubmed:author | pubmed-author:SchmidtWW | lld:pubmed |
| pubmed-article:2864344 | pubmed:author | pubmed-author:PantenUU | lld:pubmed |
| pubmed-article:2864344 | pubmed:author | pubmed-author:LenzenSS | lld:pubmed |
| pubmed-article:2864344 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2864344 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2864344 | pubmed:volume | 260 | lld:pubmed |
| pubmed-article:2864344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2864344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2864344 | pubmed:pagination | 12629-34 | lld:pubmed |
| pubmed-article:2864344 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2864344 | pubmed:meshHeading | pubmed-meshheading:2864344-... | lld:pubmed |
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| pubmed-article:2864344 | pubmed:meshHeading | pubmed-meshheading:2864344-... | lld:pubmed |
| pubmed-article:2864344 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2864344 | pubmed:articleTitle | Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria. | lld:pubmed |
| pubmed-article:2864344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2864344 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2864344 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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