| pubmed-article:286309 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C0028584 | lld:lifeskim |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C0027754 | lld:lifeskim |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C0027752 | lld:lifeskim |
| pubmed-article:286309 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:286309 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:286309 | pubmed:dateCreated | 1979-7-25 | lld:pubmed |
| pubmed-article:286309 | pubmed:abstractText | Cells of a continuous line of rat pheochromocytoma (PC12) were incubated with 125I-labeled beta nerve growth factor (beta NGF), and at given time intervals the cell nuclei were isolated by a procedure that used the detergent Triton X-100. NGF was detectable in the nucleus after 20 min and continued to accumulate in a linear fashion for several hours after the total binding to the cell had reached steady state. After 17 hr at 37 degrees C, about 60% of the NGF bound to the cell was in the nucleus, NGF was not translocated to the nucleus at 4 degrees C. When nuclei were purified from PC12 cells and incubated with 125I-labeled beta NGF, specific binding sites were found. Binding was saturable and consistent with two sites: a high-affinity site with a Kd of 0.08 nM (+/- nM) and a lower-affinity site with a Kd of 9.0 nM (+/- 2.0 nM). The receptors in the nucleus were shown to be localized to the nuclear membrane. Membrane-free chromatin did not bind NGF specifically. The translocation of NGF to the nucleus was accompanied by a commensurate decrease in the cell-surface binding capacity. In the nucleus, however, the receptor capacities of both sites were increased when PC12 cells were grown in the presence of NGF. | lld:pubmed |
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| pubmed-article:286309 | pubmed:language | eng | lld:pubmed |
| pubmed-article:286309 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:286309 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:286309 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:286309 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:286309 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:286309 | pubmed:author | pubmed-author:ShooterE MEM | lld:pubmed |
| pubmed-article:286309 | pubmed:author | pubmed-author:YanknerB ABA | lld:pubmed |
| pubmed-article:286309 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:286309 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:286309 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:286309 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:286309 | pubmed:pagination | 1269-73 | lld:pubmed |
| pubmed-article:286309 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:286309 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:286309 | pubmed:articleTitle | Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. | lld:pubmed |
| pubmed-article:286309 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:286309 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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