| pubmed-article:2854856 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0031381 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0036442 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C2346484 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C1881189 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0175668 | lld:lifeskim |
| pubmed-article:2854856 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:2854856 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2854856 | pubmed:dateCreated | 1989-7-7 | lld:pubmed |
| pubmed-article:2854856 | pubmed:abstractText | Fasted Wistar rats were given a mild level of traumatic brain injury (TBI) and then subjected to 6 min of transient forebrain ischemia 24 h posttrauma. One group was given simultaneous 1 mg/kg scopolamine and 4 mg/kg phencyclidine intraperitoneally (IP) 15 min before trauma and another group an equal volume of plasmalyte A solution. After 7 days of postinjury survival, placebo-treated rats demonstrated increased posttraumatic vulnerability to secondary ischemic CA1 neuronal death even 24 h after trauma. This finding confirmed that increased posttraumatic ischemic vulnerability persists for at least 24 h even following mild trauma. Combined muscarinic receptor and N-methyl-D-aspartate (NMDA) receptor coupled ion channel blockade given and present during the mild TBI statistically attenuated this enhanced secondary ischemic CA1 neuronal death and thus posttraumatic increased ischemic vulnerability. Placebo-treated rats had 335.3 +/- 93.6 CA1 neurons/10(6) microns 2 and drug-treated rats had 844.8 +/- 184.9 CA1 neurons/10(6) microns 2. This result suggests that muscarinic and/or NMDA receptor-mediated events confined to TBI and the early posttraumatic period are in part responsible for the phenomenon of increased posttraumatic ischemic vulnerability. | lld:pubmed |
| pubmed-article:2854856 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2854856 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2854856 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2854856 | pubmed:issn | 0897-7151 | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:BalsterR LRL | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:HayesR LRL | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:MillerL PLP | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:YoungH FHF | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:LeweltWW | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:JenkinsL WLW | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:CliftonG LGL | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:LyethB GBG | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:MoszynskiKK | lld:pubmed |
| pubmed-article:2854856 | pubmed:author | pubmed-author:DewittD SDS | lld:pubmed |
| pubmed-article:2854856 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2854856 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:2854856 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2854856 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2854856 | pubmed:pagination | 275-87 | lld:pubmed |
| pubmed-article:2854856 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2854856 | pubmed:meshHeading | pubmed-meshheading:2854856-... | lld:pubmed |
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| pubmed-article:2854856 | pubmed:meshHeading | pubmed-meshheading:2854856-... | lld:pubmed |
| pubmed-article:2854856 | pubmed:meshHeading | pubmed-meshheading:2854856-... | lld:pubmed |
| pubmed-article:2854856 | pubmed:meshHeading | pubmed-meshheading:2854856-... | lld:pubmed |
| pubmed-article:2854856 | pubmed:meshHeading | pubmed-meshheading:2854856-... | lld:pubmed |
| pubmed-article:2854856 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2854856 | pubmed:articleTitle | Combined pretrauma scopolamine and phencyclidine attenuate posttraumatic increased sensitivity to delayed secondary ischemia. | lld:pubmed |
| pubmed-article:2854856 | pubmed:affiliation | Department of Anesthesiology, Medical College of Virginia, Richmond. | lld:pubmed |
| pubmed-article:2854856 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2854856 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
