| pubmed-article:2851587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2851587 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2851587 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2851587 | lifeskim:mentions | umls-concept:C0020476 | lld:lifeskim |
| pubmed-article:2851587 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2851587 | lifeskim:mentions | umls-concept:C0052202 | lld:lifeskim |
| pubmed-article:2851587 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2851587 | pubmed:dateCreated | 1989-3-23 | lld:pubmed |
| pubmed-article:2851587 | pubmed:abstractText | We have isolated and analyzed apolipoprotein E5 gene from a patient with hyperlipoproteinemia. Apolipoprotein E5 is a variant of apolipoprotein E with two additional units of positive charge and smaller apparent molecular weight than apolipoprotein E3, which is the major isoform of apolipoprotein E. The heterozygous gene of apolipoprotein E5/3 from the patient was cloned into lambda phage. The cloned apolipoprotein E genes were subcloned into a murine retrovirus shuttle vector and were expressed. One out of four clones expressed apolipoprotein E5. The analysis of the nucleotide sequence of the exons and exon-intron boundary regions has shown a G to A substitution in the 18th nucleotide from the 5'-end of the third exon. This single base substitution changes the amino acid residue Glu to Lys at the third position from the amino-terminus of the mature protein, and gives two additional units of positive charge to the molecule. | lld:pubmed |
| pubmed-article:2851587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2851587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851587 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2851587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2851587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2851587 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2851587 | pubmed:issn | 0021-924X | lld:pubmed |
| pubmed-article:2851587 | pubmed:author | pubmed-author:YamamotoAA | lld:pubmed |
| pubmed-article:2851587 | pubmed:author | pubmed-author:YamamuraTT | lld:pubmed |
| pubmed-article:2851587 | pubmed:author | pubmed-author:TajimaSS | lld:pubmed |
| pubmed-article:2851587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2851587 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:2851587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2851587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2851587 | pubmed:pagination | 48-52 | lld:pubmed |
| pubmed-article:2851587 | pubmed:dateRevised | 2007-12-19 | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:meshHeading | pubmed-meshheading:2851587-... | lld:pubmed |
| pubmed-article:2851587 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2851587 | pubmed:articleTitle | Analysis of apolipoprotein E5 gene from a patient with hyperlipoproteinemia. | lld:pubmed |
| pubmed-article:2851587 | pubmed:affiliation | Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, Osaka, Japan. | lld:pubmed |
| pubmed-article:2851587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2851587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:348 | entrezgene:pubmed | pubmed-article:2851587 | lld:entrezgene |
