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pubmed-article:2850628pubmed:abstractTextIt is now known that various growth factors may also act in the central nervous system. Among them, it has recently been shown that epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) may possess trophic effects in the mammalian brain. We report here on the respective autoradiographic distribution of [125I]EGF and [125I]IGF-I receptor binding sites in the rat brain, both during ontogeny and in adulthood. It appears that [125I]EGF sites are mostly found in the rat forebrain during brain development. On the other hand, [125I]IGF-I sites are more widely distributed both during ontogeny and in adulthood. These results reveal the plasticity of the expression of EGF and IGF-I receptor sites in the mammalian brain. This could be relevant for the respective role of these two growth factors in the development and maintenance of neuronal function.lld:pubmed
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pubmed-article:2850628pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:2850628pubmed:articleTitleVisualization of growth factor receptor sites in rat forebrain.lld:pubmed
pubmed-article:2850628pubmed:affiliationDouglas Hospital Research Centre, McGill University, Verdun, Québec, Canada.lld:pubmed
pubmed-article:2850628pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2850628pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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