| pubmed-article:2847164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C1413560 | lld:lifeskim |
| pubmed-article:2847164 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:2847164 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:2847164 | pubmed:dateCreated | 1988-12-22 | lld:pubmed |
| pubmed-article:2847164 | pubmed:abstractText | To understand the mechanisms of oncogenesis by human T-cell leukemia virus type I, we have investigated the ability of the tax1, protein to modulate transcription of protooncogenes. By using a transient cotransfection assay, we report that the protooncogene fos promoter is transactivated by tax1 in a variety of cell types. Two regions containing upstream sequences between positions -362/-324 and -323/-276 of the c-fos promoter responded to this activation and also conferred tax1 responsiveness to the heterologous herpesvirus thymidine kinase promoter. These two sequences include elements mediating the induction by v-sis-conditioned medium and serum, phorbol ester, or epidermal growth factor, respectively. Furthermore, expression of the endogenous c-fos gene was activated by tax1 in human T-cell leukemia virus type I-infected cell lines. In contrast, no trans-activation of the c-myc or c-Ha-ras promoter was observed. | lld:pubmed |
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| pubmed-article:2847164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2847164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2847164 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2847164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2847164 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2847164 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2847164 | pubmed:author | pubmed-author:FujiiMM | lld:pubmed |
| pubmed-article:2847164 | pubmed:author | pubmed-author:VermaI MIM | lld:pubmed |
| pubmed-article:2847164 | pubmed:author | pubmed-author:Sassone-Corsi... | lld:pubmed |
| pubmed-article:2847164 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2847164 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2847164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2847164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2847164 | pubmed:pagination | 8526-30 | lld:pubmed |
| pubmed-article:2847164 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2847164 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2847164 | pubmed:articleTitle | c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. | lld:pubmed |
| pubmed-article:2847164 | pubmed:affiliation | Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92138. | lld:pubmed |
| pubmed-article:2847164 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2847164 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2847164 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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