| pubmed-article:2845810 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C0227651 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2845810 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2845810 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:2845810 | pubmed:dateCreated | 1988-11-9 | lld:pubmed |
| pubmed-article:2845810 | pubmed:abstractText | Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin and is released and/or synthesized by platelets, macrophages, endothelial cells, and rat mesangial cells. In the present investigation, we found that human glomerular mesangial cells in culture release a PDGF-like protein which competes for 125I-PDGF binding to human foreskin fibroblasts and is mitogenic for these fibroblasts. The competing and to a lesser extent the mitogenic activities present in the conditioned medium are partially recognized by an anti-PDGF antibody. Northern blot analysis of poly(A)+ RNA from human mesangial cells demonstrates the expression of both PDGF A- and B-chain mRNAs. PDGF also binds to mesangial cells in a specific manner and stimulates DNA synthesis and cell proliferation. These data suggest that a PDGF-like protein secreted by mesangial cells or released from platelets, monocytes, or endothelial cells during glomerular inflammation may function as an autocrine or a paracrine growth factor for these cells. The biological role of PDGF in mediating proliferative and other inflammatory events in the glomerulus remains to be identified. | lld:pubmed |
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| pubmed-article:2845810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2845810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2845810 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2845810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2845810 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2845810 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2845810 | pubmed:author | pubmed-author:AbboudH EHE | lld:pubmed |
| pubmed-article:2845810 | pubmed:author | pubmed-author:DiCorletoP... | lld:pubmed |
| pubmed-article:2845810 | pubmed:author | pubmed-author:ShultzP JPJ | lld:pubmed |
| pubmed-article:2845810 | pubmed:author | pubmed-author:SilverB JBJ | lld:pubmed |
| pubmed-article:2845810 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2845810 | pubmed:volume | 255 | lld:pubmed |
| pubmed-article:2845810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2845810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2845810 | pubmed:pagination | F674-84 | lld:pubmed |
| pubmed-article:2845810 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:2845810 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2845810 | pubmed:articleTitle | Mesangial cells express PDGF mRNAs and proliferate in response to PDGF. | lld:pubmed |
| pubmed-article:2845810 | pubmed:affiliation | Department of Medicine, Veterans Administration Medical Center, Cleveland, Ohio. | lld:pubmed |
| pubmed-article:2845810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2845810 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2845810 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2845810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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