pubmed-article:2845790 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0152013 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0025500 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0023401 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0332182 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
pubmed-article:2845790 | lifeskim:mentions | umls-concept:C0292524 | lld:lifeskim |
pubmed-article:2845790 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:2845790 | pubmed:dateCreated | 1988-11-16 | lld:pubmed |
pubmed-article:2845790 | pubmed:abstractText | The immunohistochemical reactivity of 38 mesotheliomas and 44 adeno-carcinomas or large cell carcinomas of the lung with monoclonal antibodies (MAb) B72.3 and Leu M1 was compared with their reactivity with the routine histochemic stains periodic acid-Schiff with diastase digestion (PAS-D) and alcian blue +/- hyaluronidase. Both MAbs reacted selectively with carcinomas when a positive test was set at greater than or equal to 10% reactive tumor cells. However, MAb B72.3 reacted with significantly more of the carcinomas (86%, chi-square test, P less than 0.01) and bound to a greater percentage of tumor cells (47 +/- 28%; mean +/- SD, t-test, P less than 0.001) than Leu M1 (57% and 25 +/- 28%, respectively). The similar reactivities of surgically resected tumor specimens and post mortem tissues with both antibodies confirmed antigen stability and suggested broad clinical utility. PAS-D stained 61% of the carcinomas. Using the markers for carcinomas (PAS-D, B72.3, and Leu M1), the tumors were classified into the correct group in 80 of 82 (98%) cases (95% confidence level: greater than 92% accuracy). The alcian blue stain was useful to confirm a diagnosis of dimorphic or epithelial mesothelioma (48% were positive). | lld:pubmed |
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pubmed-article:2845790 | pubmed:language | eng | lld:pubmed |
pubmed-article:2845790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2845790 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:2845790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2845790 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2845790 | pubmed:month | Oct | lld:pubmed |
pubmed-article:2845790 | pubmed:issn | 0002-9440 | lld:pubmed |
pubmed-article:2845790 | pubmed:author | pubmed-author:ThomDD | lld:pubmed |
pubmed-article:2845790 | pubmed:author | pubmed-author:WarnockM LML | lld:pubmed |
pubmed-article:2845790 | pubmed:author | pubmed-author:StoloffAA | lld:pubmed |
pubmed-article:2845790 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2845790 | pubmed:volume | 133 | lld:pubmed |
pubmed-article:2845790 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2845790 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2845790 | pubmed:pagination | 30-8 | lld:pubmed |
pubmed-article:2845790 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2845790 | pubmed:year | 1988 | lld:pubmed |
pubmed-article:2845790 | pubmed:articleTitle | Differentiation of adenocarcinoma of the lung from mesothelioma. Periodic acid-Schiff, monoclonal antibodies B72.3, and Leu M1. | lld:pubmed |
pubmed-article:2845790 | pubmed:affiliation | Department of Pathology, University of California, San Francisco 94143-0506. | lld:pubmed |
pubmed-article:2845790 | pubmed:publicationType | Journal Article | lld:pubmed |
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