| pubmed-article:2843305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0012694 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0886658 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0079043 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:2843305 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:2843305 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2843305 | pubmed:dateCreated | 1988-10-21 | lld:pubmed |
| pubmed-article:2843305 | pubmed:abstractText | The effect of nedocromil sodium (4 mg; 7.8 X 10(-6) M) on adenosine-induced bronchoconstriction was compared with that of a higher dose of sodium cromoglycate (10 mg; 24.1 X 10(-6) M). Eleven allergic asthmatic patients (mean age 26.28 +/- 12.21 years) were studied. Adenosine (0.03-4.00 mg) was administered as nebulized aerosol. The dose of adenosine producing a 20% change in FEV1(PD20) was calculated from the individual semi-logarithmic dose-response curves. Patients were studied on 4 separate days. On the first day the adenosine challenge was performed; on subsequent days patients were pretreated (20 min before challenge) with either placebo or test drug (nedocromil sodium 2 x 2 mg or sodium cromoglycate 2 x 5 mg) administered by pressurized aerosol in a randomized, double-blind manner. Statistical analysis was performed by two-way analysis of variance. Neither sodium cromoglycate nor nedocromil sodium showed a significant bronchodilator effect. In patients treated with placebo, inhalation of adenosine produced a dose-related bronchoconstriction with a geometric mean PD20 of 0.42 mg. After drug administration the mean PD20 values were 1.29 mg with sodium cromoglycate and 2.30 mg with nedocromil sodium. Both drugs produced a significant increase in mean PD20 value in comparison with placebo and baseline (P less than 0.01). These results demonstrate that nedocromil sodium (4 mg) is significantly more potent than a larger dose of sodium cromoglycate (10 mg) in inhibiting adenosine-induced bronchoconstriction (P less than 0.05). | lld:pubmed |
| pubmed-article:2843305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2843305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2843305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2843305 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2843305 | pubmed:issn | 0009-9090 | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:MistrettaAA | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:PalermoFF | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:OliveriRR | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:PolosaRR | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:CrimiNN | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:PalermoBB | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:MaccarroneCC | lld:pubmed |
| pubmed-article:2843305 | pubmed:author | pubmed-author:VancheriCC | lld:pubmed |
| pubmed-article:2843305 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2843305 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:2843305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2843305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2843305 | pubmed:pagination | 367-74 | lld:pubmed |
| pubmed-article:2843305 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2843305 | pubmed:meshHeading | pubmed-meshheading:2843305-... | lld:pubmed |
| pubmed-article:2843305 | pubmed:meshHeading | pubmed-meshheading:2843305-... | lld:pubmed |
| pubmed-article:2843305 | pubmed:meshHeading | pubmed-meshheading:2843305-... | lld:pubmed |
| pubmed-article:2843305 | pubmed:meshHeading | pubmed-meshheading:2843305-... | lld:pubmed |
| pubmed-article:2843305 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2843305 | pubmed:articleTitle | Comparative study of the effects of nedocromil sodium (4 mg) and sodium cromoglycate (10 mg) on adenosine-induced bronchoconstriction in asthmatic subjects. | lld:pubmed |
| pubmed-article:2843305 | pubmed:affiliation | Institute of Respiratory Diseases, University of Catania, Italy. | lld:pubmed |
| pubmed-article:2843305 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2843305 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2843305 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2843305 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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