| pubmed-article:2843236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0028937 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0205112 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0028631 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:2843236 | lifeskim:mentions | umls-concept:C0162585 | lld:lifeskim |
| pubmed-article:2843236 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2843236 | pubmed:dateCreated | 1988-10-27 | lld:pubmed |
| pubmed-article:2843236 | pubmed:abstractText | The action of cyclic nucleotides on the short-circuit current across the isolated bullfrog olfactory mucosa was studied both in the absence and presence of odorants. 8-Bromo-cAMP applied to the ciliated side of the mucosa caused a concentration-dependent, reversible increase in the basal short-circuit current, but not when it was applied to the submucosal side. The current had a sigmoidal concentration dependence described by the Hill equation. The magnitude of the odorant-evoked current was enhanced after bathing the ciliated side with cAMP analogs or modulators of intracellular cAMP. GTP gamma S added to the ciliated side increased the odorant-evoked current, while GDP beta S caused a decrease. Current transients induced by stimulating the ciliated side with either pulses of odorant or 8-bromo-cAMP were partially suppressed by amiloride, but only when amiloride and stimulant were presented simultaneously. Pulses of 8-bromo-cAMP and odorant presented simultaneously resulted in currents that added nonlinearly. In the absence of odorant, 8-bromo-cGMP caused a concentration-dependent decrease in net inward current that was reversed by 8-bromo-cAMP. Odorant-evoked currents were also reduced by 8-bromo-cGMP, and these could not be reversed by 8-bromo-cAMP. The results indicate that one type of olfactory transduction process involves the activation by cAMP of an inward current through an amiloride-sensitive apical ion channel and that this mechanism is mediated by a stimulatory G-protein. | lld:pubmed |
| pubmed-article:2843236 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2843236 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2843236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2843236 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2843236 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:2843236 | pubmed:author | pubmed-author:GetchellT VTV | lld:pubmed |
| pubmed-article:2843236 | pubmed:author | pubmed-author:DeSimoneJ AJA | lld:pubmed |
| pubmed-article:2843236 | pubmed:author | pubmed-author:HeckG LGL | lld:pubmed |
| pubmed-article:2843236 | pubmed:author | pubmed-author:PersaudK CKC | lld:pubmed |
| pubmed-article:2843236 | pubmed:author | pubmed-author:DeSimoneS KSK | lld:pubmed |
| pubmed-article:2843236 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2843236 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2843236 | pubmed:volume | 944 | lld:pubmed |
| pubmed-article:2843236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2843236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2843236 | pubmed:pagination | 49-62 | lld:pubmed |
| pubmed-article:2843236 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:meshHeading | pubmed-meshheading:2843236-... | lld:pubmed |
| pubmed-article:2843236 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2843236 | pubmed:articleTitle | Ion transport across the frog olfactory mucosa: the action of cyclic nucleotides on the basal and odorant-stimulated states. | lld:pubmed |
| pubmed-article:2843236 | pubmed:affiliation | Department of Physiology and Biophysics, Medical College of Virginia, Richmond. | lld:pubmed |
| pubmed-article:2843236 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2843236 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2843236 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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