| pubmed-article:2842345 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0015980 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0035693 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:2842345 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:2842345 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2842345 | pubmed:dateCreated | 1988-9-29 | lld:pubmed |
| pubmed-article:2842345 | pubmed:abstractText | Stimulation of normal human foreskin fibroblasts with platelet-derived growth factor (PDGF) was inhibited by the addition of the synthetic double-stranded RNA polyinosinic-polycytidylic acid (poly-I:C) as measured by incorporation of 3H-thymidine (3H-TdR). Single-stranded polycytidylic or polyinosinic acid had no effect. Double-stranded RNA is an inducer of interferon-beta (IFN-beta) in fibroblasts. On the mRNA level, an expression of IFN-beta 2 but not of IFN-beta 1 was seen after addition of PDGF and/or poly-I:C. The inhibition of PDGF-induced mitogenesis was completely blocked by an antiserum to IFN-beta. Poly-I:C did not interfere with PDGF binding to its receptor, nor did it block protein synthesis, indicating that the inhibition is not due to a nonspecific toxic effect of the double-stranded RNA but rather is mediated by IFN-beta. The present study implies that the IFN-beta system in fibroblasts is a very potent autocrine inhibitory pathway. | lld:pubmed |
| pubmed-article:2842345 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2842345 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2842345 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2842345 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2842345 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:2842345 | pubmed:author | pubmed-author:WestermarkBB | lld:pubmed |
| pubmed-article:2842345 | pubmed:author | pubmed-author:ForsbergKK | lld:pubmed |
| pubmed-article:2842345 | pubmed:author | pubmed-author:PaulssonYY | lld:pubmed |
| pubmed-article:2842345 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2842345 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:2842345 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2842345 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2842345 | pubmed:pagination | 266-72 | lld:pubmed |
| pubmed-article:2842345 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
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| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:meshHeading | pubmed-meshheading:2842345-... | lld:pubmed |
| pubmed-article:2842345 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2842345 | pubmed:articleTitle | Effect on platelet-derived growth factor-induced mitogenesis of double-stranded RNA: evidence for an autocrine growth inhibition mediated by interferon-beta. | lld:pubmed |
| pubmed-article:2842345 | pubmed:affiliation | Department of Pathology, University of Uppsala, Sweden. | lld:pubmed |
| pubmed-article:2842345 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2842345 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2842345 | lld:pubmed |
