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| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C1512796 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C1706204 | lld:lifeskim |
| pubmed-article:2839703 | lifeskim:mentions | umls-concept:C1555721 | lld:lifeskim |
| pubmed-article:2839703 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2839703 | pubmed:dateCreated | 1988-8-19 | lld:pubmed |
| pubmed-article:2839703 | pubmed:abstractText | We recently described a protocol for determination of retrovirus mutation rates, that is, the mutation frequency in a single cycle of retrovirus replication (J.P. Dougherty and H.M. Temin, Mol. Cell. Biol. 6:4378-4395, 1987; J.P. Dougherty and H.M. Temin, p. 18-23, in J. H. Miller and M. P. Calos, ed., Gene Transfer Vectors for Mammalian Cells, 1987). We used this protocol to determine the mutation rates for defined mutations in a replicating retrovirus by using a spleen necrosis virus-based vector. We determined that the mutation rate for a single base pair substitution during replication of this avian retrovirus is 2 x 10(-5) per base pair per replication cycle and the insertion rate is 10(-7) per base pair per replication cycle. It will be possible to use this protocol to determine mutation rates for other retroviruses. | lld:pubmed |
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| pubmed-article:2839703 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2839703 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2839703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2839703 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2839703 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:2839703 | pubmed:author | pubmed-author:TeminH MHM | lld:pubmed |
| pubmed-article:2839703 | pubmed:author | pubmed-author:DoughertyJ... | lld:pubmed |
| pubmed-article:2839703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2839703 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2839703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2839703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2839703 | pubmed:pagination | 2817-22 | lld:pubmed |
| pubmed-article:2839703 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2839703 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2839703 | pubmed:articleTitle | Determination of the rate of base-pair substitution and insertion mutations in retrovirus replication. | lld:pubmed |
| pubmed-article:2839703 | pubmed:affiliation | McArdle Laboratory, University of Wisconsin, Madison 53706. | lld:pubmed |
| pubmed-article:2839703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2839703 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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