| pubmed-article:2839696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0042760 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0042338 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0042219 | lld:lifeskim |
| pubmed-article:2839696 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:2839696 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2839696 | pubmed:dateCreated | 1988-8-19 | lld:pubmed |
| pubmed-article:2839696 | pubmed:abstractText | Varicella-zoster virus (VZV) encodes several glycoproteins which are present on both mature viral envelopes and the surfaces of infected cell membranes. Mechanisms of VZV glycoprotein transport and virion envelopment were investigated by both continuous radiolabeling and pulse-chase analyses with tritiated fucose in VZV-infected cells. We studied in detail the large cytoplasmic vacuoles which were present in infected cells but absent from uninfected cells. The specific activity in each subcellular compartment was defined by quantitative electron microscope autoradiography, using a cross-fire probability matrix analysis to more accurately assess the individual compartment demarcated by the silver grains. By these techniques, we documented a progression of activity originating in the Golgi apparatus and traveling through the post-Golgi region into virus-induced cytoplasmic vacuoles and finally to areas of the cellular membrane associated with the egress of viral particles. Significant amounts of radiolabel were not observed in the nucleus, and only low levels of radiolabel were associated with the cellular membrane not involved with the egress of viral particles. In addition, immunolabeling of Lowicryl-embedded VZV-infected cells demonstrated the presence of VZV glycoproteins within cytoplasmic vacuole membranes as well as on virion envelopes. These observations suggested that cytoplasmic vacuoles harbored VZV-specified glycoproteins and were also the predominant site of VZV virion envelopment within the infected cell. Neither enveloped nor unenveloped viral particles were observed within the Golgi apparatus itself. | lld:pubmed |
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| pubmed-article:2839696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2839696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2839696 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2839696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2839696 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2839696 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:2839696 | pubmed:author | pubmed-author:JonesFF | lld:pubmed |
| pubmed-article:2839696 | pubmed:author | pubmed-author:GroseCC | lld:pubmed |
| pubmed-article:2839696 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2839696 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2839696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2839696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2839696 | pubmed:pagination | 2701-11 | lld:pubmed |
| pubmed-article:2839696 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2839696 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2839696 | pubmed:articleTitle | Role of cytoplasmic vacuoles in varicella-zoster virus glycoprotein trafficking and virion envelopment. | lld:pubmed |
| pubmed-article:2839696 | pubmed:affiliation | Department of Microbiology, University of Iowa College of Medicine, Iowa City 52242. | lld:pubmed |
| pubmed-article:2839696 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2839696 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2839696 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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