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pubmed-article:2839386pubmed:abstractTextThe ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.lld:pubmed
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pubmed-article:2839386pubmed:articleTitleInterferon-gamma induces class II MHC antigens on RINm5F cells.lld:pubmed
pubmed-article:2839386pubmed:affiliationDepartment of Immunology, Middlesex Hospital Medical School, London, England.lld:pubmed
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