| pubmed-article:2838524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0001407 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0028027 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C0242417 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:2838524 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2838524 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2838524 | pubmed:dateCreated | 1988-8-3 | lld:pubmed |
| pubmed-article:2838524 | pubmed:abstractText | Human monocytes purified by elutriation were cultured for 3 d in Teflon bags with or without human recombinant interferon-gamma (rIFN gamma). The cells were then collected and used in suspension to determine the rate of stimulus-dependent superoxide or hydrogen peroxide formation as a measure of the NADPH-oxidase. The treatment with IFN gamma increased this rate two- to threefold when phorbol myristate acetate (PMA) was used as the stimulus. By contrast, no IFN gamma-dependent increase in superoxide production was observed when the cells were stimulated with different concentrations of the receptor agonist N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe) alone or in combination with another receptor agonist, platelet-activating factor (PAF). At optimum concentrations, f-Met-Leu-Phe elicited rates of superoxide formation that could not be exceeded under other stimulatory conditions including PMA after treatment with IFN gamma. It thus appears that f-Met-Leu-Phe can lead to maximum activation of the NADPH-oxidase, and that this response is not influenced by IFN gamma. Treatment with IFN gamma also failed to affect the affinity of PMA- or f-Met-Leu-Phe-stimulated oxidase for NADPH, the Km values being 30 to 40 microM under all conditions. IFN gamma did not alter the cellular levels of cytochrome b558, as measured by low-temperature spectroscopy, and protein kinase C, as measured by [3H]phorbol dibutyrate binding, and did not appreciably influence the stimulus-dependent increase of cytosolic free calcium. These results indicate that activation of human mononuclear phagocytes by IFN gamma does not affect the level and the kinetic properties of NADPH-oxidase or its activation by receptor agonists. They confirm, however, that IFN gamma enhances the respiratory burst response to PMA. | lld:pubmed |
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| pubmed-article:2838524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2838524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2838524 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2838524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2838524 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2838524 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2838524 | pubmed:author | pubmed-author:BaggioliniMM | lld:pubmed |
| pubmed-article:2838524 | pubmed:author | pubmed-author:ThelenMM | lld:pubmed |
| pubmed-article:2838524 | pubmed:author | pubmed-author:WolfMM | lld:pubmed |
| pubmed-article:2838524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2838524 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:2838524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2838524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2838524 | pubmed:pagination | 1889-95 | lld:pubmed |
| pubmed-article:2838524 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2838524 | pubmed:year | 1988 | lld:pubmed |
