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pubmed-article:2835813pubmed:abstractTextThe human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are two distinct human retroviruses that infect T cells. Recent epidemiologic studies have identified a cohort of individuals that are coinfected with both viruses. It is reported here that human peripheral blood leukocytes infected with HIV-1 in vitro can be induced to produce large quantities of HIV-1 after mitogenic stimulation by noninfectious HTLV-I virions. It is also shown that HTLV-I virions may exert this effect prior to, immediately following, or well after the cells are infected with HIV-1. These results provide further impetus for epidemiologic studies of dually infected individuals to determine whether HTLV-I may act as a cofactor for acquired immunodeficiency syndrome (AIDS).lld:pubmed
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pubmed-article:2835813pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2835813pubmed:articleTitleHIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation.lld:pubmed
pubmed-article:2835813pubmed:affiliationDivision of Hematology-Oncology, UCLA School of Medicine 90024.lld:pubmed
pubmed-article:2835813pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2835813pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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