| pubmed-article:2835169 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C0085112 | lld:lifeskim |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:2835169 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:2835169 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2835169 | pubmed:dateCreated | 1988-6-14 | lld:pubmed |
| pubmed-article:2835169 | pubmed:abstractText | scid mice lack detectable B and T lymphocytes; there are no typical pre-B cells as defined by c mu and surface markers in their bone marrow and their thymus contains only 1% of the normal number of cells. In these characters scid mice seem to lack lymphoid stem cells. However, some mice have detectable serum immunoglobulin and others develop thymomas; both observations indicate that the block in lymphoid development is not absolute. To determine whether scid mice have any B-cell precursors, we looked for pre-B cells by their ability to be transformed by Abelson murine leukemia virus (A-MuLV). Surprisingly, scid mice contain as many B-cell precursors transformable with A-MuLV as normal control mice. Cell-surface markers specific for pre-B and B cells were detected on the A-MuLV-transformed bone marrow cells of both scid and normal mice, indicating that the A-MuLV-transformed cells belong to the B lineage. Interestingly, the same surface markers were undetectable on nontransformed scid bone marrow cells. We conclude from these results that scid mice have normal numbers of early B-cell precursors but that their differentiation into functional B cells is severely impaired. | lld:pubmed |
| pubmed-article:2835169 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2835169 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2835169 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2835169 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2835169 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2835169 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2835169 | pubmed:author | pubmed-author:PhillipsR ARA | lld:pubmed |
| pubmed-article:2835169 | pubmed:author | pubmed-author:BosmaM JMJ | lld:pubmed |
| pubmed-article:2835169 | pubmed:author | pubmed-author:BosmaG CGC | lld:pubmed |
| pubmed-article:2835169 | pubmed:author | pubmed-author:FulopG MGM | lld:pubmed |
| pubmed-article:2835169 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2835169 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2835169 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:2835169 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2835169 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2835169 | pubmed:pagination | 192-201 | lld:pubmed |
| pubmed-article:2835169 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:2835169 | pubmed:meshHeading | pubmed-meshheading:2835169-... | lld:pubmed |
| pubmed-article:2835169 | pubmed:meshHeading | pubmed-meshheading:2835169-... | lld:pubmed |
| pubmed-article:2835169 | pubmed:meshHeading | pubmed-meshheading:2835169-... | lld:pubmed |
| pubmed-article:2835169 | pubmed:meshHeading | pubmed-meshheading:2835169-... | lld:pubmed |
| pubmed-article:2835169 | pubmed:meshHeading | pubmed-meshheading:2835169-... | lld:pubmed |
| pubmed-article:2835169 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2835169 | pubmed:articleTitle | Early B-cell precursors in scid mice: normal numbers of cells transformable with Abelson murine leukemia virus (A-MuLV). | lld:pubmed |
| pubmed-article:2835169 | pubmed:affiliation | Department of Medical Biophysics, University of Toronto, Canada. | lld:pubmed |
| pubmed-article:2835169 | pubmed:publicationType | Journal Article | lld:pubmed |
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