| pubmed-article:2834021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:2834021 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:2834021 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2834021 | pubmed:dateCreated | 1988-5-31 | lld:pubmed |
| pubmed-article:2834021 | pubmed:abstractText | It has been proposed that activation of a calcium-sensitive protease (calpain) is a crucial step in the induction of long-term potentiation (LTP). To test this hypothesis, we used chronic recording techniques to measure the effects of intraventricular infusion of leupeptin, a calpain inhibitor, on LTP in the hippocampus. Rats implanted bilaterally with stimulating electrodes in the Schaffer-commissural system and one recording electrode in the apical dendrites of field CA1 were fitted with osmotic mini-pumps delivering either leupeptin (20 mg/ml) or saline at a rate of 0.5 microliter/h into the lateral ventricle. Short bursts of high-frequency stimulation with the bursts delivered at 5/s were used to induce LTP in those animals which had stable responses for several days. Rats in the saline group (n = 11) exhibited an immediate LTP effect that remained in place over successive days of testing, while only 3 of 13 leupeptin treated animals showed evidence of LTP 24 h after high-frequency stimulation, and in only one of those was a sizeable effect recorded over several days. The average change in responses at the 24-h test point was +33% for the controls and +4% for the leupeptin group (P less than 0.01). The block of LTP induction was reversible, since high-frequency stimulation applied after disconnecting the pumps led to a robust LTP effect that lasted for several days in 6 of 7 animals tested. There were no detectable differences in baseline responses in the presence and absence of leupeptin. | lld:pubmed |
| pubmed-article:2834021 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2834021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2834021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2834021 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2834021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2834021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2834021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2834021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2834021 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2834021 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2834021 | pubmed:author | pubmed-author:BaudryMM | lld:pubmed |
| pubmed-article:2834021 | pubmed:author | pubmed-author:LynchGG | lld:pubmed |
| pubmed-article:2834021 | pubmed:author | pubmed-author:StaubliUU | lld:pubmed |
| pubmed-article:2834021 | pubmed:author | pubmed-author:LaudalO AOA | lld:pubmed |
| pubmed-article:2834021 | pubmed:author | pubmed-author:ThibaultOO | lld:pubmed |
| pubmed-article:2834021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2834021 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2834021 | pubmed:volume | 444 | lld:pubmed |
| pubmed-article:2834021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2834021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2834021 | pubmed:pagination | 153-8 | lld:pubmed |
| pubmed-article:2834021 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
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| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:meshHeading | pubmed-meshheading:2834021-... | lld:pubmed |
| pubmed-article:2834021 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2834021 | pubmed:articleTitle | Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses. | lld:pubmed |
| pubmed-article:2834021 | pubmed:affiliation | Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717. | lld:pubmed |
| pubmed-article:2834021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2834021 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2834021 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2834021 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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