| pubmed-article:2829714 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2829714 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:2829714 | lifeskim:mentions | umls-concept:C0021270 | lld:lifeskim |
| pubmed-article:2829714 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:2829714 | lifeskim:mentions | umls-concept:C0001367 | lld:lifeskim |
| pubmed-article:2829714 | lifeskim:mentions | umls-concept:C1382107 | lld:lifeskim |
| pubmed-article:2829714 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2829714 | pubmed:dateCreated | 1988-3-11 | lld:pubmed |
| pubmed-article:2829714 | pubmed:abstractText | Eighteen children from 3 weeks to 6.9 years of age were given an oral acyclovir suspension for herpes simplex or varicella-zoster virus infections. Thirteen patients who were 6 months to 6.9 years old received 600 mg/m2 per dose, and three infants and two children less than 2 years old were given 300 mg/m2 per dose. The drug was given four times a day, except to one infant who was treated with three doses a day. Among the 13 children who received the 600-mg/m2 dose, the maximum concentration in plasma (Cmax) was 0.99 +/- 0.38 microgram/ml (mean +/- standard deviation), the time to maximum concentration (Tmax) was 3.0 +/- 0.86 h, the area under the curve (AUC) was 5.56 +/- 2.17 micrograms.h/ml, and the elimination half-life (t1/2) was 2.59 +/- 0.78 h. The three infants less than 2 months of age who received the 300-mg/m2 dose had a Cmax of 1.88 +/- 1.11 micrograms/ml, a Tmax of 4.10 +/- 0.48 h, an AUC of 6.54 +/- 4.32 micrograms.h/ml, and a t1/2 of 3.26 +/- 0.33 h. The acyclovir suspension was well tolerated by young children. No adverse effects requiring discontinuation of the drug occurred. | lld:pubmed |
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| pubmed-article:2829714 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2829714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2829714 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2829714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2829714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2829714 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2829714 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2829714 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:WellerSS | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:ConnorJ DJD | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:LevinM JMJ | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:StraubeRR | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:ArvinA MAM | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:BlumM RMR | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:ChapmanSS | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:SullenderW... | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:DiazP SPS | lld:pubmed |
| pubmed-article:2829714 | pubmed:author | pubmed-author:DanknerWW | lld:pubmed |
| pubmed-article:2829714 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2829714 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2829714 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2829714 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2829714 | pubmed:pagination | 1722-6 | lld:pubmed |
| pubmed-article:2829714 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2829714 | pubmed:meshHeading | pubmed-meshheading:2829714-... | lld:pubmed |
| pubmed-article:2829714 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2829714 | pubmed:articleTitle | Pharmacokinetics of acyclovir suspension in infants and children. | lld:pubmed |
| pubmed-article:2829714 | pubmed:affiliation | Department of Pediatrics, Stanford University School of Medicine, California 94305. | lld:pubmed |
| pubmed-article:2829714 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2829714 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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