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pubmed-article:2825689pubmed:abstractTextInhibin, a hormone produced by Sertoli cells in response to FSH, regulates androgen production in nearby Leydig cells. Beta-endorphin synthesized by Leydig cells under LH control is also known to regulate Sertoli function. To delineate whether beta-endorphin might constitute part of a short loop regulatory system between these two testicular cells, the effect of this opiate on inhibin secretion was examined. Beta-endorphin alone did not alter basal inhibin accumulation in primary Sertoli cell-enriched cultures, however it did significantly reduce FSH-induced inhibin production and adenylyl cyclase activity but had no effect on forskolin-stimulated inhibin accumulation or adenylyl cyclase activity. Other opioid peptides (ACTH, dMSH, methionine-enkephalin) were without effect. These observations suggest that beta-endorphin regulates inhibin secretion by inhibiting FSH receptor coupling to adenylyl cyclase.lld:pubmed
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pubmed-article:2825689pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2825689pubmed:articleTitleBeta-endorphin regulation of FSH-stimulated inhibin production is a component of a short loop system in testis.lld:pubmed
pubmed-article:2825689pubmed:affiliationPopulation Council, New York, NY 10021.lld:pubmed
pubmed-article:2825689pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2825689pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2825689pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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