| pubmed-article:2822433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C0066908 | lld:lifeskim |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2822433 | lifeskim:mentions | umls-concept:C0066808 | lld:lifeskim |
| pubmed-article:2822433 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2822433 | pubmed:dateCreated | 1987-11-27 | lld:pubmed |
| pubmed-article:2822433 | pubmed:abstractText | The benzophenone chromophore has been incorporated into a synthetic amino acid (p-benzoyl-L-phenylalanine; L-Bpa) to produce a chemically stable photoaffinity probe. L-Bpa was found to retain the photochemical reactivity of benzophenone. To test the utility of this synthetic amino acid as a photo-reactive probe for receptors, a tetrapeptide analog of morphiceptin was made as a model peptide in which the C-terminal prolinamide was replaced by L-Bpa amide. The affinity of the mu opioid receptor for this peptide is comparable to that for the parent compound, morphiceptin. Irradiation of the peptide-receptor complex reduced the subsequent binding of [3H]naloxone and virtually eliminated that of [3H]Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO). Binding studies with [3H]naloxone indicated that both the affinity and the capacity were reduced. Competition studies with [3H]D-Ala2-D-Leu5-enkephalin (DADLE) and naloxone indicated selective inactivation of a mu type opioid receptor. | lld:pubmed |
| pubmed-article:2822433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2822433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2822433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2822433 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2822433 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2822433 | pubmed:author | pubmed-author:KauerJ CJC | lld:pubmed |
| pubmed-article:2822433 | pubmed:author | pubmed-author:TamS WSW | lld:pubmed |
| pubmed-article:2822433 | pubmed:author | pubmed-author:HerblinW FWF | lld:pubmed |
| pubmed-article:2822433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2822433 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:2822433 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:2822433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2822433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2822433 | pubmed:pagination | 273-9 | lld:pubmed |
| pubmed-article:2822433 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
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| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:meshHeading | pubmed-meshheading:2822433-... | lld:pubmed |
| pubmed-article:2822433 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2822433 | pubmed:articleTitle | Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog. | lld:pubmed |
| pubmed-article:2822433 | pubmed:affiliation | Medical Products Department, E.I. du Pont de Nemours and Company, Wilmington, DE 19898. | lld:pubmed |
| pubmed-article:2822433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2822433 | pubmed:publicationType | In Vitro | lld:pubmed |
